Department of Endocrinology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Endocrinology, Shenzhen Hospital, Southern Medical University, Shenzhen, China.
BMC Cardiovasc Disord. 2023 Jan 25;23(1):47. doi: 10.1186/s12872-023-03081-6.
Corrected QT (QTc) interval has been reported to be associated with type 2 diabetes. This study aimed to explore the relationship between different glucose tolerance and QTc intervals among middle-aged and older Chinese individuals.
We conducted a cross-sectional analysis that included 9898 subjects (3194 men and 6704 women) in a Chinese population. Glucose tolerance was studied during the oral glucose tolerance test (OGTT). Insulin, blood pressure, hemoglobin A1c (HbA1c), serum lipids, hepatic transaminases and waist-to-hip ratio were assessed. The QTc interval was derived from ECG recordings, and the subjects were stratified based on different glucose tolerance.
QTc interval levels were increased significantly in the subjects with abnormal glucose metabolism compared with the normal glucose regulation group. Multiple regression analyses showed that the QTc interval was significantly associated with fasting plasma glucose, 2-h OGTT plasma glucose and HbA1c. The odds ratio of prolonged QTc was 1.396 for impaired glucose regulation (IFG)/impaired fasting glucose (IGT) (95% CI 0.126-1.730), and 1.342 for type 2 diabetes (95% CI 0.142-1.577) after all potential confounders were adjusted.
Impaired glucose tolerance (IGR) and diabetes are associated with prolonged QTc intervals among middle-aged and older Chinese individuals. Abnormal glucose regulation can be used to monitor the QTc interval in the population.
校正的 QT（QTc）间期与 2 型糖尿病有关。本研究旨在探讨中国中老年人群中不同糖耐量与 QTc 间期的关系。
我们进行了一项横断面分析，纳入了中国人群中的 9898 名受试者（3194 名男性和 6704 名女性）。葡萄糖耐量在口服葡萄糖耐量试验（OGTT）期间进行研究。评估了胰岛素、血压、糖化血红蛋白（HbA1c）、血清脂质、肝转氨酶和腰臀比。从心电图记录中得出 QTc 间期，根据不同的葡萄糖耐量对受试者进行分层。
与正常葡萄糖调节组相比，代谢异常的受试者 QTc 间期水平显著升高。多元回归分析显示，QTc 间期与空腹血糖、2 小时 OGTT 血糖和 HbA1c 显著相关。糖耐量受损（IFG）/空腹血糖受损（IGT）的 QTc 延长比值比为 1.396（95%CI 0.126-1.730），2 型糖尿病的比值比为 1.342（95%CI 0.142-1.577），所有潜在混杂因素调整后。
在中国中老年人群中，糖耐量受损（IGR）和糖尿病与 QTc 间期延长有关。异常葡萄糖调节可用于监测人群中的 QTc 间期。
