Department of Ophthalmology, Asan Medical Center, University of Ulsan, College of Medicine, 88 Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Korea.
Asan Diabetes Center, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea.
BMC Ophthalmol. 2023 Jan 25;23(1):34. doi: 10.1186/s12886-023-02788-6.
To identify factors associated with microvascular recovery after intravitreal bevacizumab or panretinal photocoagulation (PRP) in diabetic retinopathy (DR).
We retrospectively reviewed 320 eyes/patients with DR treated with intravitreal bevacizumab and/or PRP. Two consecutive fluorescein angiographies (FAs) of each eye were compared. The number of microaneurysms and the area of capillary non-perfusion were calculated automatically using ImageJ software. Microvascular recovery was defined as a marked reduction in the numbers of microaneurysms (< 20%) or a marked reduction in the area of capillary non-perfusion (< 50%) in 45-degree fields or a complete regression of new vessels in ETDRS 7 standard fields. Baseline FA findings and changes in the ocular and systemic factors were analyzed.
Twenty-eight (8.8%) of the 320 total eyes were found to meet the criteria of microvascular recovery after the treatments. Multivariate analysis revealed the presence of diffuse capillary telangiectasis (P = .003) and late disc leaking (P = .007) on baseline FA and a reduction of glycated hemoglobin (P = .005) during the follow-up period were predictive factors of microvascular recovery after the treatments. Although the microvascular recovery group presented with a significant improvement of BCVA after the treatments, the baseline BCVA could not predict the microvascular recovery after the treatments.
Diffuse capillary telangiectasis or late disc leaking on baseline FA and improved glycemic control positively predicted the microvascular recovery after treatments for DR.
为了确定与糖尿病视网膜病变（DR）患者接受玻璃体内贝伐单抗或全视网膜光凝（PRP）后微血管恢复相关的因素。
我们回顾性分析了 320 只接受玻璃体内贝伐单抗和/或 PRP 治疗的 DR 眼/患者。比较了每只眼的连续两次荧光素眼底血管造影（FA）。使用 ImageJ 软件自动计算微动脉瘤的数量和毛细血管无灌注区的面积。微血管恢复定义为 45°视野中微动脉瘤数量明显减少（<20%）或毛细血管无灌注区面积明显减少（<50%），或 ETDRS 7 标准视野中新血管完全消退。分析了基线 FA 表现以及眼部和全身因素的变化。
320 只眼中有 28 只（8.8%）符合治疗后微血管恢复的标准。多变量分析显示，基线 FA 上弥漫性毛细血管扩张（P=0.003）和晚期盘状渗漏（P=0.007）以及随访期间糖化血红蛋白降低（P=0.005）是治疗后微血管恢复的预测因素。尽管微血管恢复组在治疗后视力 BCVA 有显著改善，但基线 BCVA 不能预测治疗后的微血管恢复。
基线 FA 上弥漫性毛细血管扩张或晚期盘状渗漏以及血糖控制改善可预测 DR 患者治疗后的微血管恢复。
Zotero 插件
