Edmonds Rhea, Schönborn Linda, Habben Sunke, Paparoupa Maria, Greinacher Andreas, Schuppert Frank
Department of Gastroenterology, Endocrinology, Diabetology and General Medicine Klinikum Kassel Kassel Germany.
Campus Kassel of the University of Southampton Southampton UK.
Clin Case Rep. 2023 Jan 20;11(1):e6883. doi: 10.1002/ccr3.6883. eCollection 2023 Jan.
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare clinical condition that has emerged during the mass immunization against SARS-CoV-2. Reports indicate that VITT may also be induced by other vaccines, such as the human papillomavirus vaccine, or occur independently of vaccination. Its recognition requires a high index of suspicion, especially in patients presenting with thrombocytopenia and thrombosis several days after vaccination with an adenoviral vector-based vaccine against SARS-CoV-2. Bleeding manifestations do not exclude VITT, as initially assumed. It is of great importance to perform the appropriate diagnostic tests early in the course of the disease, as false-negative results may occur and many aspects of VITT are not fully understood. These two cases from Germany demonstrate unusual presentations of VITT.
疫苗诱导的免疫性血栓性血小板减少症（VITT）是一种在大规模接种严重急性呼吸综合征冠状病毒2（SARS-CoV-2）疫苗期间出现的罕见临床病症。报告表明，VITT也可能由其他疫苗诱导，如人乳头瘤病毒疫苗，或在未接种疫苗的情况下独立发生。识别VITT需要高度的怀疑指数，尤其是在接种基于腺病毒载体的SARS-CoV-2疫苗几天后出现血小板减少和血栓形成的患者中。出血表现并不像最初设想的那样排除VITT。在疾病早期进行适当的诊断测试非常重要，因为可能会出现假阴性结果，而且VITT的许多方面尚未完全了解。来自德国的这两例病例展示了VITT的不寻常表现。
