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一种能对细菌微环境变化做出反应的抗菌性骨内植入物表面涂层。

Antibacterial intraosseous implant surface coating that responds to changes in the bacterial microenvironment.

作者信息

Bai Xin, Yu Jiawei, Xiao Jie, Wang Yanping, Li Zhe, Wang Hao

机构信息

Jiande First People's Hospital, Hangzhou, Zhejiang, China.

Zhuji Affiliated Hospital of Wenzhou Medical University, Shaoxing, Zhejiang, China.

出版信息

Front Bioeng Biotechnol. 2023 Jan 9;10:1016001. doi: 10.3389/fbioe.2022.1016001. eCollection 2022.

DOI:10.3389/fbioe.2022.1016001
PMID:36698645
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9868547/
Abstract

Bone implant-associated infection is one of the most challenging problems encountered by orthopedic surgeons. There is considerable interest in the development of drug-loaded antibacterial coatings for the surfaces of metal implants. However, it is difficult to achieve the stable local release of an effective drug dose for many antibacterial coatings. In the present study, analyses of the thickness and water contact angle of multiple layers confirmed the successful assembly of multilamellar membrane structures. Measurement of the zone of bacterial inhibition indicated gradual degradation of the (montmorillonite [MMT]/hyaluronic acid [HA]) multilamellar film structure with concentration-dependent degradation during incubation with hyaluronidase solution and . results resembled the results. Overall, the findings confirm that the (MMT/HA-rifampicin) multilamellar film structure exhibits good antibacterial properties and excellent biocompatibility. Further studies of the clinical potential of the antibacterial coating prepared in this experiment are warranted.

摘要

骨植入物相关感染是骨科医生面临的最具挑战性的问题之一。人们对开发用于金属植入物表面的载药抗菌涂层非常感兴趣。然而，对于许多抗菌涂层来说，实现有效药物剂量的稳定局部释放是困难的。在本研究中，对多层膜的厚度和水接触角的分析证实了多层膜结构的成功组装。细菌抑制圈的测量表明，在与透明质酸酶溶液孵育期间，（蒙脱石[MMT]/透明质酸[HA]）多层膜结构逐渐降解，且降解具有浓度依赖性。结果与结果相似。总体而言，研究结果证实（MMT/HA-利福平）多层膜结构具有良好的抗菌性能和优异的生物相容性。有必要进一步研究本实验制备的抗菌涂层的临床潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b79/9868547/0deb7f6c8a4a/fbioe-10-1016001-g012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b79/9868547/32a0fe4418a9/fbioe-10-1016001-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b79/9868547/fb8c27b40d62/fbioe-10-1016001-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b79/9868547/9a7c7ab12f70/fbioe-10-1016001-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b79/9868547/6aeaabcb6a6f/fbioe-10-1016001-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b79/9868547/6db34e67dfa9/fbioe-10-1016001-g010.jpg
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