用于无创定量新生儿胆红素和血红蛋白浓度的手持式漫反射光谱系统：一项初步研究。
Handheld diffuse reflectance spectroscopy system for noninvasive quantification of neonatal bilirubin and hemoglobin concentrations: a pilot study.
作者信息
Cheng Nan-Yu, Tzeng Shih-Yu, Fang Ming-Chein, Kuo Chun-Yen, Lu Wen-Hsien, Yang Chin-Chieh, Tseng Sheng-Hao
机构信息
Department of Photonics, National Cheng Kung University, No. 1, University Road, Tainan City 701, Taiwan.
Department of Health-Business Administration, Fooyin University, No. 151 Jinxue Rd., Daliao Dist., Kaohsiung, 831, Taiwan.
出版信息
Biomed Opt Express. 2022 Dec 20;14(1):467-476. doi: 10.1364/BOE.475531. eCollection 2023 Jan 1.
The prevalence rate of neonatal jaundice can reach 80%, of which 5% may develop dangerous hemolytic jaundice. The blood test for obtaining bilirubin and hemoglobin concentration is the gold standard for diagnosing hemolytic jaundice; however, frequently drawing blood from jaundice neonates for the screening purpose is not practical. We have developed a handheld diffuse reflectance spectroscopy system to noninvasively determine the bilirubin and hemoglobin levels in neonates. Our study showed that the correlation coefficients were 0.95 and 0.80 for bilirubin and hemoglobin between the results from the blood tests and our handheld system, respectively. This handheld system could be an effective tool for screening hemolytic jaundice.
新生儿黄疸的患病率可达80%，其中5%可能发展为危险性溶血性黄疸。获取胆红素和血红蛋白浓度的血液检测是诊断溶血性黄疸的金标准；然而，频繁地从黄疸新生儿身上采血用于筛查并不实际。我们开发了一种手持式漫反射光谱系统，以无创方式测定新生儿的胆红素和血红蛋白水平。我们的研究表明，血液检测结果与我们的手持式系统所测胆红素和血红蛋白的相关系数分别为0.95和0.80。这种手持式系统可能是筛查溶血性黄疸的有效工具。
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