Movahedi Mohammad Mehdi, Karimaghaei Gholam Reza, Noori Ahmad, Atefi Mohammad, Mahmoudi Tahereh, Gheisari Farshid
Department of Medical Physics and Biomedical Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Ionizing and Non- Ionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran.
Galen Med J. 2022 Nov 15;11:e2397. doi: 10.31661/gmj.v11i.2397. eCollection 2022.
Despite the benefits of radioactive iodine (RAI) therapy as an adjunctive treatment for thyroid cancer, it can be associated with several side effects. The main purpose of this study was to determine the changes in serum alkaline phosphatase (ALP), calcium (Ca), and parathyroid hormone (PTH) at different doses of RAI therapy among patients who were referred to the nuclear medicine department of Namazi Hospital, Shiraz. This cross-sectional study was conducted on 60 patients with papillary thyroid cancer who underwent RAI therapy at different doses of 100, 150, and 200 mCi. The ALP, Ca, and PTH levels of patients were measured before and 60 days after RAI therapy. Our study revealed that RAI therapy at all doses significantly increased ALP level in comparison with baseline amounts (P≤0.05). However, changes in PTH and Ca levels were not significant among patients who received different doses of RAI (P˃0.05). RAI therapy could affect important hormones and enzymes such as ALP and PTH. This issue can be considered in diagnostic and therapeutic prescriptions of RAI for the treatment of thyroid cancer..
尽管放射性碘（RAI）疗法作为甲状腺癌的辅助治疗有诸多益处，但它可能会引发多种副作用。本研究的主要目的是确定在设拉子纳马齐医院核医学科接受治疗的患者中，不同剂量RAI疗法下血清碱性磷酸酶（ALP）、钙（Ca）和甲状旁腺激素（PTH）的变化情况。这项横断面研究针对60例接受100、150和200毫居里不同剂量RAI治疗的乳头状甲状腺癌患者展开。在RAI治疗前及治疗后60天测量患者的ALP、Ca和PTH水平。我们的研究表明，与基线水平相比，所有剂量的RAI治疗均显著提高了ALP水平（P≤0.05）。然而，接受不同剂量RAI治疗的患者中，PTH和Ca水平的变化并不显著（P˃0.05）。RAI治疗可能会影响诸如ALP和PTH等重要激素和酶。在RAI治疗甲状腺癌的诊断和治疗处方中可考虑这一问题。
