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Heme Oxygenase-1 (HMOX1) Gene Polymorphisms as Predictive Markers of Increased Risk of Thrombosis among Patients with COVID-19:

作者信息

Shakir Mohammed Mai, Abdelsamea Mohamedahmed Khalid

机构信息

Department of Hematology, Faculty of Medical Laboratory Sciences, University of Gezira, Wad Medani, Sudan.

Department of Immunology, Faculty of Medical Laboratory Sciences, University of Gezira, Wad Medani, Sudan.

出版信息

Galen Med J. 2022 Nov 16;11:e2398. doi: 10.31661/gmj.v11i.2398. eCollection 2022.

DOI:10.31661/gmj.v11i.2398
PMID:36698696
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9838105/
Abstract
摘要

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Heme Oxygenase-1 (HMOX1) Gene Polymorphisms as Predictive Markers of Increased Risk of Thrombosis among Patients with COVID-19:血红素加氧酶-1（HMOX1）基因多态性作为COVID-19患者血栓形成风险增加的预测标志物：
Galen Med J. 2022 Nov 16;11:e2398. doi: 10.31661/gmj.v11i.2398. eCollection 2022.
2
Heme Oxygenase-1 (HMOX1) Gene Polymorphisms, Thrombosis and COVID-19: Correspondence.血红素加氧酶-1（HMOX1）基因多态性、血栓形成与2019冠状病毒病：通信
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Heme oxygenase-1 deficiency accelerates formation of arterial thrombosis through oxidative damage to the endothelium, which is rescued by inhaled carbon monoxide.血红素加氧酶-1缺乏通过对内皮的氧化损伤加速动脉血栓形成，吸入一氧化碳可挽救这种损伤。
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Effect of heme oxygenase-1 polymorphisms on lung function and gene expression.血红素加氧酶-1 多态性对肺功能和基因表达的影响。
BMC Med Genet. 2011 Sep 8;12:117. doi: 10.1186/1471-2350-12-117.
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An association between polymorphism of the heme oxygenase-1 and -2 genes and age-related macular degeneration.血红素加氧酶-1 和 -2 基因多态性与年龄相关性黄斑变性的相关性。
Mol Biol Rep. 2012 Mar;39(3):2081-7. doi: 10.1007/s11033-011-0955-3. Epub 2011 Jun 7.
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Heme oxygenase-1 suppresses a pro-inflammatory phenotype in monocytes and determines endothelial function and arterial hypertension in mice and humans.血红素加氧酶-1抑制单核细胞中的促炎表型，并确定小鼠和人类的血管内皮功能和动脉高血压。
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Short (GT)n microsatellite repeats in the heme oxygenase-1 gene promoter are associated with antioxidant and anti-inflammatory status in Mexican pediatric patients with sepsis.短（GT）n 微卫星重复序列在血红素加氧酶-1 基因启动子中与墨西哥败血症儿科患者的抗氧化和抗炎状态相关。
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Alternative 5' untranslated regions are involved in expression regulation of human heme oxygenase-1.非翻译区 5' 参与了人血红素加氧酶-1 的表达调控。
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引用本文的文献

1
Heme Oxygenase-1 (HMOX1) Gene Polymorphisms, Thrombosis and COVID-19: Correspondence.血红素加氧酶-1（HMOX1）基因多态性、血栓形成与2019冠状病毒病：通信
Galen Med J. 2023 Jun 14;12:e2952. doi: 10.31661/gmj.v12i0.2952. eCollection 2023.

本文引用的文献

1
The Role of Heme Oxygenase-1 Promoter Polymorphisms in Perinatal Disease.血红素加氧酶-1 启动子多态性在围产疾病中的作用。
Int J Environ Res Public Health. 2021 Mar 29;18(7):3520. doi: 10.3390/ijerph18073520.
2
The Perfect Storm: COVID-19 Health Disparities in US Blacks.《完美风暴：美国黑人的 COVID-19 健康差异》
J Racial Ethn Health Disparities. 2021 Oct;8(5):1153-1160. doi: 10.1007/s40615-020-00871-y. Epub 2020 Sep 23.
3
Thrombosis in COVID-19.COVID-19 相关血栓形成。
Am J Hematol. 2020 Dec;95(12):1578-1589. doi: 10.1002/ajh.25982. Epub 2020 Sep 16.
4
COVID19 and increased mortality in African Americans: socioeconomic differences or does the renin angiotensin system also contribute?新冠病毒与非裔美国人死亡率上升：社会经济差异还是肾素血管紧张素系统也有影响？
J Hum Hypertens. 2020 Nov;34(11):764-767. doi: 10.1038/s41371-020-0380-y. Epub 2020 Jul 15.
5
Why African Americans Are a Potential Target for COVID-19 Infection in the United States.为何非裔美国人在美国是新冠病毒感染的潜在目标人群。
J Med Internet Res. 2020 Jun 12;22(6):e19934. doi: 10.2196/19934.
6
COVID-19 and thrombosis: Beyond a casual association.新型冠状病毒肺炎与血栓形成：不仅仅是偶然关联。
Med Clin (Barc). 2020 Jul 10;155(1):44. doi: 10.1016/j.medcli.2020.04.014. Epub 2020 May 11.
7
Genetic susceptibility for COVID-19-associated sudden cardiac death in African Americans.非裔美国人中与新冠病毒相关的心源性猝死的遗传易感性。
Heart Rhythm. 2020 Sep;17(9):1487-1492. doi: 10.1016/j.hrthm.2020.04.045. Epub 2020 May 5.
8
Heme oxygenase-1 promoter (GT) polymorphism associates with HIV neurocognitive impairment.血红素加氧酶-1 启动子（GT）多态性与 HIV 神经认知障碍相关。
Neurol Neuroimmunol Neuroinflamm. 2020 Apr 10;7(3). doi: 10.1212/NXI.0000000000000710. Print 2020 May.
9
Increased risk of venous thromboembolism is associated with genetic variation in heme oxygenase-1 in Blacks.黑人中血红素加氧酶-1 的遗传变异与静脉血栓栓塞风险增加相关。
Thromb Res. 2012 Dec;130(6):942-7. doi: 10.1016/j.thromres.2012.08.300. Epub 2012 Sep 7.
10
Genetic variation in heme oxygenase 1 (HMOX1) and the risk of recurrent venous thromboembolism.血红素加氧酶1（HMOX1）的基因变异与复发性静脉血栓栓塞的风险
J Vasc Surg. 2008 Mar;47(3):566-70. doi: 10.1016/j.jvs.2007.09.060. Epub 2008 Jan 16.