Hamami Chamgordani Zahra, Mazaheri Mohammad, Iraj Bijan, Baghshahi Hojjat, Sabouhi Fakhri
Department of Adult Health Nursing, Faculty of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.
Persian Medicine, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Avicenna J Phytomed. 2023 Jan-Feb;13(1):34-44. doi: 10.22038/AJP.2022.21175.
Medicinal plants with fewer side effects and low cost than synthetic medicines are increasingly advised to treat diseases. The present study aimed to identify compounds and evaluate the plant's effects on hyperglycemic and hyperlipidemia indices, and liver, and kidney function.
Following identification of using GC/MS method, 72 participants were randomly divided into two groups (n=36 per group), receiving oral hypoglycemic medication (metformin) with or without 50 ml hydrosol twice a day for three months as intervention and placebo control, respectively. Body mass index (BMI), systolic and diastolic blood pressure, fasting blood sugar (FBS), glycosylated hemoglobin (HbA1c), total cholesterol, triglyceride, HDL-C, and LDL-C levels were measured at the beginning and end of the experiment. Also, aspartate transaminase, alanine transaminase, blood urea nitrogen, and creatinine levels were measured to assess adverse effects on liver and kidney functions.
The main components were terpenes with 46.69% of the total ingredients of essential oil. Other prominent compounds identified included octanoic acid (12.14 %) and isoxazole (6.72 %). Intergroup changes in blood parameters showed that hydrosol for three months could significantly reduce HbA1C and blood cholesterol levels but did not affect other measured parameters. Also, there were no adverse effects on kidney or liver function.
The present findings showed that the consumption of 50 ml of hydrosol as a complementary treatment in diabetic patients reduced HbA1C and cholesterol levels without adverse effects on the liver or kidneys functions.
与合成药物相比，副作用更少且成本更低的药用植物越来越多地被建议用于治疗疾病。本研究旨在鉴定化合物，并评估该植物对高血糖和高血脂指标以及肝肾功能的影响。
采用气相色谱/质谱法鉴定后，72名参与者被随机分为两组（每组n = 36），分别接受口服降糖药物（二甲双胍），一组每天两次服用50毫升水溶胶作为干预措施，另一组服用安慰剂作为对照，为期三个月。在实验开始和结束时测量体重指数（BMI）、收缩压和舒张压、空腹血糖（FBS）、糖化血红蛋白（HbA1c）、总胆固醇、甘油三酯、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）水平。此外，测量天冬氨酸转氨酶、丙氨酸转氨酶、血尿素氮和肌酐水平，以评估对肝肾功能的不良影响。
主要成分是萜类化合物，占精油总成分的46.69%。鉴定出的其他主要化合物包括辛酸（12.14%）和异恶唑（6.72%）。组间血液参数变化表明，服用三个月的水溶胶可显著降低HbA1C和血液胆固醇水平，但不影响其他测量参数。此外，对肾功能或肝功能没有不良影响。
本研究结果表明，糖尿病患者每天服用50毫升水溶胶作为辅助治疗可降低HbA1C和胆固醇水平，且对肝肾功能无不良影响。
