新冠疫情后状况下的睡眠障碍:患病率与生活质量
Sleep disturbance in post COVID-19 conditions: Prevalence and quality of life.
作者信息
Tedjasukmana Rimawati, Budikayanti Astri, Islamiyah Wardah Rahmatul, Witjaksono Anastasia Melissa Ayu Larasati, Hakim Manfaluthy
机构信息
Faculty of Medicine, Universitas Kristen Krida Wacana, Jakarta, Indonesia.
Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
出版信息
Front Neurol. 2023 Jan 9;13:1095606. doi: 10.3389/fneur.2022.1095606. eCollection 2022.
Post COVID-19 conditions are complaints and symptoms in patients with a history of probable or confirmed COVID-19 after 3 months of the onset of COVID-19 and last at least 2 months. About 10-20% of people may experience post COVID-19 conditions, one of which is sleep disturbance. There is a wide range of prevalence of sleep disturbances from 6% to more than 70%. An online survey of the post COVID-19 conditions in various countries showed that 78.58% of subjects had sleep disturbances, including insomnia, sleep-disordered breathing, central disorders of hypersomnolence, circadian rhythm sleep-wake disorders, parasomnias, and sleep-related movement disorders. Sleep disturbance can be found starting from 2 weeks until 48 weeks or more after discharge or after having a negative COVID-19 test results. Women aged < 50 years old with severe COVID-19 infection reported a worse outcome. Several mechanisms may cause sleep disturbance in post COVID-19 condition, namely persistent viral infection and inflammation, immunity dysregulation, and mitochondrial dysfunction. Several studies discovered sleep disturbance was a major problem that affected different domains of QoL in post COVID-19 conditions. Significant correlation was found between several dimensions of SF-36 with moderate-to-severe insomnia in post COVID-19 conditions. Therefore, sleep disturbance is a major problem in post COVID-19 conditions and may affect patients' QoL, and the existence of sleep disturbance should be a concern in post COVID-19 conditions period. Further research is required to determine the prevalence based on agreed definition as well as methods to assess this condition and its impact on QoL.
新冠后状况是指有疑似或确诊新冠病史的患者在新冠发病3个月后出现的不适和症状,且持续至少2个月。约10%-20%的人可能会出现新冠后状况,其中之一就是睡眠障碍。睡眠障碍的患病率范围很广,从6%到70%以上不等。一项关于各国新冠后状况的在线调查显示,78.58%的受试者存在睡眠障碍,包括失眠、睡眠呼吸紊乱、中枢性过度嗜睡障碍、昼夜节律睡眠-觉醒障碍、异态睡眠和睡眠相关运动障碍。从出院后或新冠检测结果呈阴性后2周直到48周或更久,都可能出现睡眠障碍。报告显示,年龄<50岁的女性若感染严重新冠,其预后较差。新冠后状况下睡眠障碍可能由多种机制引起,即持续性病毒感染和炎症、免疫失调以及线粒体功能障碍。多项研究发现,睡眠障碍是影响新冠后状况患者生活质量不同领域的一个主要问题。在新冠后状况下,SF-36的几个维度与中重度失眠之间存在显著相关性。因此,睡眠障碍是新冠后状况中的一个主要问题,可能会影响患者的生活质量,在新冠后状况期间,睡眠障碍的存在应引起关注。需要进一步研究以根据商定的定义确定患病率,以及评估这种状况及其对生活质量影响的方法。