Natesan Vijayakumar, Kim Sung-Jin
Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Tamil Nadu 608002, India.
Department of Pharmacology and Toxicology, Metabolic Diseases Research Laboratory, School of Dentistry, Kyung Hee University, Seoul 02447, Republic of Korea.
Biomol Ther (Seoul). 2025 Jan 1;33(1):39-53. doi: 10.4062/biomolther.2024.142. Epub 2024 Dec 5.
Diabetic kidney disease (DKD) poses a major global health challenge, affecting millions of individuals and contributing to substantial morbidity and mortality. Traditional treatments have focused primarily on managing symptoms and slowing disease progression rather than reversing or halting kidney damage. However, recent advancements in natural compound research have unveiled promising new avenues for therapeutic development. Extensive research has been conducted to showcase the antioxidant advantages for kidney health, supporting the potential effectiveness of natural and synthetic products in clinical and experimental research. Bioactive substances found in large quantities in food, such as polyphenols, have emerged as adjuvants. This review manuscript aims to provide a comprehensive overview of natural compounds and their potential efficacy, mechanisms of action, and clinical applications in the prevention and treatment of various kidney diseases. This review emphasizes the connection between oxidative stress and inflammation in diabetic nephropathy (DN), which leads to harmful effects on kidney cells due to pathological damage. A lower incidence of DM2-related problems and a slower progression of end-stage renal disease have been associated with the consumption of these compounds.
糖尿病肾病（DKD）是一项重大的全球健康挑战，影响着数百万人，并导致大量发病和死亡。传统治疗主要集中在控制症状和减缓疾病进展，而非逆转或阻止肾脏损伤。然而，天然化合物研究的最新进展为治疗开发开辟了新的前景。已经开展了广泛研究以展示其对肾脏健康的抗氧化优势，支持天然和合成产品在临床和实验研究中的潜在有效性。在食物中大量发现的生物活性物质，如多酚，已成为辅助剂。本综述旨在全面概述天然化合物及其在预防和治疗各种肾脏疾病中的潜在功效、作用机制和临床应用。本综述强调糖尿病肾病（DN）中氧化应激与炎症之间的联系，这种联系由于病理损伤而对肾细胞产生有害影响。食用这些化合物与2型糖尿病相关问题的较低发病率和终末期肾病的较慢进展有关。
