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促红细胞生成素对新生儿缺氧缺血性脑病的影响：随机对照试验的最新荟萃分析。

The effect of erythropoietin on neonatal hypoxic-ischemic encephalopathy: An updated meta-analysis of randomized control trials.

作者信息

Pan Jing-Jing, Wu Yue, Liu Yun, Cheng Rui, Chen Xiao-Qing, Yang Yang

机构信息

First Affiliated Hospital, Nanjing Medical University, Nanjing, China.

Children's Hospital of Nanjing Medical University, Nanjing Children's Hospital, Nanjing, China.

出版信息

Front Pediatr. 2023 Jan 9;10:1074287. doi: 10.3389/fped.2022.1074287. eCollection 2022.

DOI:10.3389/fped.2022.1074287
PMID:36699298
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9869948/
Abstract

OBJECTIVE

Erythropoietin (EPO) seems to have a good application prospect both in experimental models and patients with hypoxic ischaemic encephalopathy (HIE). Data regarding the effect of EPO on death or neurodevelopmental impairment are conflicting.

METHODS

A search was conducted by two investigators involved in this research in PubMed, Embase, and Cochrane databases for studies in English, in Wanfang, VIP, and Cnki databases for Chinese studies (all last launched on 2022/08/31). Ultimately, we identified 11 original studies, including the EPO group ( = 636) and the control group ( = 626). Odds ratio (OR) and weighted mean difference were calculated using a random effects or fixed effects model, depending on the data type and heterogeneity of the included studies.

RESULTS

  1. The comparison of effectiveness of EPO treatment on HIE: (1) With respect to death, data showed no significant difference between EPO and control groups (OR = 0.97, 95% CI, 0.66-1.43;  = 0.88); Considering the additional effect of mild hypothermia treatment (MHT), no significant difference was found between EPO + MHT/control + MHT groups either (OR = 1.09, 95% CI, 0.69-1.73;  = 0.72); With respect to the interference of different routes of medication administration, Meta-analysis further showed no difference between intravenous EPO/control groups (OR = 1.13, 95% CI, 0.70-1.82;  = 0.62). (2) With respect to cerebral palsy, the analysis showed no significant difference (OR = 0.76, 95% CI, 0.50-1.15;  = 0.20); Considering the effect of MHT and routes of medication administration, data further showed no difference between EPO group and control group (OR = 1.26, 95% CI, 0.73-2.19;  = 0.41). (3) Regarding epilepsy, no significant difference was found (OR = 0.49, 95% CI, 0.20-1.19;  = 0.12). MR abnormality was less common in EPO group (OR = 0.39, 95% CI, 0.19-0.79;  = 0.008). 2. The comparison of possible adverse events of EPO: EPO treatment would not increase the risk of thrombocytopenia, hypotension, and hepatic and kidney injury.

CONCLUSIONS

This meta-analysis showed that EPO treatment is not beneficial for reducing death and improving neurological impairment, though it would not increase the risk of adverse events.

摘要

目的

促红细胞生成素（EPO）在缺氧缺血性脑病（HIE）的实验模型和患者中似乎都有良好的应用前景。关于EPO对死亡或神经发育障碍影响的数据存在冲突。

方法

两名参与本研究的研究人员在PubMed、Embase和Cochrane数据库中检索英文研究，在万方、维普和知网数据库中检索中文研究（均截至2022年8月31日）。最终，我们确定了11项原始研究，包括EPO组（n = 636）和对照组（n = 626）。根据纳入研究的数据类型和异质性，使用随机效应或固定效应模型计算比值比（OR）和加权平均差。

结果

  1. EPO治疗HIE的疗效比较：（1）关于死亡，数据显示EPO组和对照组之间无显著差异（OR = 0.97，95%CI，0.66 - 1.43；I² = 0.88）；考虑亚低温治疗（MHT）的附加作用，EPO + MHT/对照组 + MHT组之间也未发现显著差异（OR = 1.09，95%CI，0.69 - 1.73；I² = 0.72）；关于不同给药途径的影响，Meta分析进一步显示静脉注射EPO/对照组之间无差异（OR = 1.13，95%CI，0.70 - 1.82；I² = 0.62）。（2）关于脑瘫，分析显示无显著差异（OR = 0.76，95%CI，0.50 - 1.15；I² = 0.20）；考虑MHT和给药途径的影响，数据进一步显示EPO组和对照组之间无差异（OR = 1.26，95%CI，0.73 - 2.19；I² = 0.41）。（3）关于癫痫，未发现显著差异（OR = 0.49，95%CI，0.20 - 1.19；I² = 0.12）。EPO组的磁共振成像异常较少见（OR = 0.39，95%CI，0.19 - 0.79；I² = 0.008）。2. EPO可能的不良事件比较：EPO治疗不会增加血小板减少、低血压以及肝肾功能损伤的风险。

结论

这项Meta分析表明，EPO治疗虽不会增加不良事件风险，但对降低死亡风险和改善神经功能障碍并无益处。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1907/9869948/6505621d25c2/fped-10-1074287-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1907/9869948/3ad3c97a97b4/fped-10-1074287-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1907/9869948/e64911291a58/fped-10-1074287-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1907/9869948/151e268cccea/fped-10-1074287-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1907/9869948/6505621d25c2/fped-10-1074287-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1907/9869948/d62562d284c4/fped-10-1074287-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1907/9869948/a981d51cbe2e/fped-10-1074287-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1907/9869948/14467f24aba7/fped-10-1074287-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1907/9869948/7e8795cd554c/fped-10-1074287-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1907/9869948/3ad3c97a97b4/fped-10-1074287-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1907/9869948/e64911291a58/fped-10-1074287-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1907/9869948/151e268cccea/fped-10-1074287-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1907/9869948/6505621d25c2/fped-10-1074287-g008.jpg

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2
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3
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4
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