COVID-19大流行对四个欧洲国家与常见精神障碍相关的初级保健利用的差异影响:一项回顾性观察研究。
Differential impact of the COVID-19 pandemic on primary care utilization related to common mental disorders in four European countries: A retrospective observational study.
作者信息
Flodin Pär, Sörberg Wallin Alma, Tarantino Barbara, Cerchiello Paola, Mladá Karolína, Kuklová Marie, Kondrátová Lucie, Parimbelli Enea, Osika Walter, Hollander Anna-Clara, Dalman Christina
机构信息
Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.
Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
出版信息
Front Psychiatry. 2023 Jan 9;13:1045325. doi: 10.3389/fpsyt.2022.1045325. eCollection 2022.
BACKGROUND
The COVID-19 pandemic is commonly believed to have increased common mental disorders (CMD, i.e., depression and anxiety), either directly due to COVID-19 contractions (death of near ones or residual conditions), or indirectly by increasing stress, economic uncertainty, and disruptions in daily life resulting from containment measure. Whereas studies reporting on initial changes in self-reported data frequently have reported increases in CMD, pandemic related changes in CMD related to primary care utilization are less well known. Analyzing time series of routinely and continuously sampled primary healthcare data from Sweden, Norway, Netherlands, and Latvia, we aimed to characterize the impact of the pandemic on CMD recorded prevalence in primary care. Furthermore, by relating these changes to country specific time-trajectories of two classes of containment measures, we evaluated the differential impact of containment strategies on CMD rates. Specifically, we wanted to test whether school restrictions would preferentially affect age groups corresponding to those of school children or their parents.
METHODS
For the four investigated countries, we collected time-series of monthly counts of unique CMD patients in primary healthcare from the year 2015 (or 2017) until 2021. Using pre-pandemic timepoints to train seasonal Auto Regressive Integrated Moving Average (ARIMA) models, we predicted healthcare utilization during the pandemic. Discrepancies between observed and expected time series were quantified to infer pandemic related changes. To evaluate the effects of COVID-19 measures on CMD related primary care utilization, the predicted time series were related to country specific time series of levels of social distancing and school restrictions.
RESULTS
In all countries except Latvia there was an initial (April 2020) decrease in CMD care prevalence, where largest drops were found in Sweden (Prevalence Ratio, PR = 0.85; 95% CI 0.81-0.90), followed by Netherlands (0.86; 95% CI 0.76-1.02) and Norway (0.90; 95% CI 0.83-0.98). Latvia on the other hand experienced increased rates (1.25; 95% CI 1.08-1.49). Whereas PRs in Norway and Netherlands normalized during the latter half of 2020, PRs stayed low in Sweden and elevated in Latvia. The overall changes in PR during the pandemic year 2020 was significantly changed only for Sweden (0.91; 95% CI 0.90-0.93) and Latvia (1.20; 95% CI 1.14-1.26). Overall, the relationship between containment measures and CMD care prevalence were weak and non-significant. In particular, we could not observe any relationship of school restriction to CMD care prevalence for the age groups best corresponding to school children or their parents.
CONCLUSION
Common mental disorders prevalence in primary care decreased during the initial phase of the COVID-19 pandemic in all countries except from Latvia, but normalized in Norway and Netherlands by the latter half of 2020. The onset of the pandemic and the containment strategies were highly correlated within each country, limiting strong conclusions on whether restriction policy had any effects on mental health. Specifically, we found no evidence of associations between school restrictions and CMD care prevalence. Overall, current results lend no support to the common belief that the pandemic severely impacted the mental health of the general population as indicated by healthcare utilization, apart from in Latvia. However, since healthcare utilization is affected by multiple factors in addition to actual need, future studies should combine complementary types of data to better understand the mental health impacts of the pandemic.
背景
人们普遍认为,新冠疫情增加了常见精神障碍(CMD,即抑郁症和焦虑症)的发生,这要么是由于感染新冠病毒(亲人死亡或遗留病症)直接导致的,要么是由于防控措施增加了压力、经济不确定性以及日常生活受到干扰而间接导致的。尽管报告自我报告数据初始变化的研究经常报告CMD有所增加,但与初级保健利用相关的CMD的疫情相关变化却鲜为人知。通过分析来自瑞典、挪威、荷兰和拉脱维亚的常规和连续抽样的初级医疗保健数据的时间序列,我们旨在描述疫情对初级保健中记录的CMD患病率的影响。此外,通过将这些变化与两类防控措施的国家特定时间轨迹相关联,我们评估了防控策略对CMD发病率的不同影响。具体而言,我们想测试学校限制措施是否会优先影响与学龄儿童或其父母年龄组相对应的人群。
方法
对于四个被调查的国家,我们收集了2015年(或2017年)至2021年期间初级医疗保健中每月独特CMD患者数量的时间序列。利用疫情前的时间点训练季节性自回归积分移动平均(ARIMA)模型,我们预测了疫情期间的医疗保健利用率。对观察到的和预期的时间序列之间的差异进行量化,以推断与疫情相关的变化。为了评估新冠措施对与CMD相关的初级保健利用的影响,将预测的时间序列与国家特定的社会距离和学校限制水平的时间序列相关联。
结果
除拉脱维亚外,所有国家的CMD护理患病率在初期(2020年4月)均有所下降,瑞典下降幅度最大(患病率比值,PR = 0.85;95%置信区间0.81 - 0.90),其次是荷兰(0.86;95%置信区间0.76 - 1.02)和挪威(0.90;95%置信区间0.83 - 0.98)。另一方面,拉脱维亚的患病率有所上升(1.25;95%置信区间1.08 - 1.49)。挪威和荷兰的PR值在2020年下半年恢复正常,而瑞典的PR值仍然较低,拉脱维亚则持续升高。2020年疫情期间PR的总体变化仅在瑞典(0.91;95%置信区间0.90 - 0.93)和拉脱维亚(1.20;95%置信区间1.14 - 1.26)有显著变化。总体而言,防控措施与CMD护理患病率之间的关系较弱且不显著。特别是,对于与学龄儿童或其父母最对应的年龄组,我们没有观察到学校限制与CMD护理患病率之间的任何关系。
结论
在新冠疫情的初始阶段,除拉脱维亚外,所有国家初级保健中的常见精神障碍患病率均有所下降,但挪威和荷兰在2020年下半年恢复正常。疫情的爆发和防控策略在每个国家内部高度相关,这限制了关于限制政策是否对心理健康有任何影响的有力结论。具体而言,我们没有发现学校限制与CMD护理患病率之间存在关联的证据。总体而言,目前的结果不支持普遍观点,即除拉脱维亚外,疫情严重影响了普通人群的心理健康,这是由医疗保健利用率所表明的。然而,由于医疗保健利用率除了实际需求外还受到多种因素的影响,未来的研究应结合互补类型的数据,以更好地了解疫情对心理健康的影响。
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