Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain.
Universitat Autònoma de Barcelona, Barcelona, Spain.
BMJ Open. 2022 Apr 8;12(4):e057866. doi: 10.1136/bmjopen-2021-057866.
To investigate how trends in incidence of anxiety and depressive disorders have been affected by the COVID-19 pandemic.
Population-based cohort study.
Retrospective cohort study from 2018 to 2021 using the Information System for Research in Primary Care (SIDIAP) database in Catalonia, Spain.
3 640 204 individuals aged 18 or older in SIDIAP on 1 March 2018 with no history of anxiety and depressive disorders.
The incidence of anxiety and depressive disorders during the prelockdown period (March 2018-February 2020), lockdown period (March-June 2020) and postlockdown period (July 2020-March 2021) was calculated. Forecasted rates over the COVID-19 periods were estimated using negative binomial regression models based on prelockdown data. The percentage of reduction was estimated by comparing forecasted versus observed events, overall and by sex, age and socioeconomic status.
The incidence rates per 100 000 person-months of anxiety and depressive disorders were 151.1 (95% CI 150.3 to 152.0) and 32.3 (31.9 to 32.6), respectively, during the prelockdown period. We observed an increase of 37.1% (95% prediction interval 25.5 to 50.2) in incident anxiety diagnoses compared with the expected in March 2020, followed by a reduction of 15.8% (7.3 to 23.5) during the postlockdown period. A reduction in incident depressive disorders occurred during the lockdown and postlockdown periods (45.6% (39.2 to 51.0) and 22.0% (12.6 to 30.1), respectively). Reductions were higher among women during the lockdown period, adults aged 18-34 years and individuals living in the most deprived areas.
The COVID-19 pandemic in Catalonia was associated with an initial increase in anxiety disorders diagnosed in primary care but a reduction in cases as the pandemic continued. Diagnoses of depressive disorders were lower than expected throughout the pandemic.
研究 COVID-19 大流行如何影响焦虑和抑郁障碍发病率的变化趋势。
基于西班牙加泰罗尼亚地区初级保健研究信息系统（SIDIAP）数据库的 2018 年至 2021 年的回顾性队列研究。
使用西班牙加泰罗尼亚地区初级保健研究信息系统（SIDIAP）数据库的回顾性队列研究。
SIDIAP 数据库中 2018 年 3 月 1 日年龄在 18 岁或以上且无焦虑和抑郁障碍病史的 3640204 人。
计算了锁定前时期（2018 年 3 月至 2020 年 2 月）、锁定时期（2020 年 3 月至 6 月）和锁定后时期（2020 年 7 月至 2021 年 3 月）的焦虑和抑郁障碍的发病率。使用基于锁定前数据的负二项式回归模型来估计 COVID-19 期间的预测发病率。通过比较预测与实际事件，总体以及按性别、年龄和社会经济地位来评估减少的百分比。
在锁定前时期，焦虑和抑郁障碍的发病率分别为每 100000 人月 151.1（95%CI 150.3 至 152.0）和 32.3（31.9 至 32.6）。与 2020 年 3 月的预期相比，我们观察到焦虑症诊断的发病率增加了 37.1%（95%预测区间 25.5 至 50.2），随后在锁定后时期减少了 15.8%（7.3 至 23.5）。锁定和锁定后时期抑郁障碍的发病率均有所下降（分别为 45.6%（39.2 至 51.0）和 22.0%（12.6 至 30.1））。在锁定期间，女性、18-34 岁的成年人和生活在最贫困地区的人降幅更大。
加泰罗尼亚的 COVID-19 大流行与初级保健中诊断出的焦虑障碍的最初增加有关，但随着大流行的继续，病例有所减少。整个大流行期间，抑郁障碍的诊断率均低于预期。
