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中国宁波一家三级医院小儿烧伤创面感染患者的临床特征及微生物学调查:一项十年回顾性研究

The clinical characteristics and microbiological investigation of pediatric burn patients with wound infections in a tertiary hospital in Ningbo, China: A ten-year retrospective study.

作者信息

Ke Yefang, Ye Lina, Zhu Pan, Zhu Zhe

机构信息

Department of Clinical Laboratory, Ningbo Women and Children's Hospital, Ningbo, Zhejiang, China.

Neonatal Intensive Care Unit, Ningbo Women and Children's Hospital, Ningbo, Zhejiang, China.

出版信息

Front Microbiol. 2023 Jan 9;13:1034099. doi: 10.3389/fmicb.2022.1034099. eCollection 2022.

Abstract

Burn is one of the leading causes of death and disability in children worldwide, and wound infection is an excellent challenge in burn treatment. We performed a retrospective review of pediatric burn patients with wound infections to reveal their clinical data and investigate pathogens' distribution and drug resistance patterns to provide references for treatment. As a result, 330 pediatric burn patients with wound infections were identified; 65.8% (217/330) were < 2 years old. Most of the injuries were scalded and involved <10% total body surface area in size (TBSA), mainly causing II-degree burn and II + III-degree burn. Three hundred and fifty nine strains of pathogens were isolated, the primary pathogens were (45.4%) and (18.7%). Both and isolated from 2012 to 2016 were more likely to be multi-resistant than those isolated from 2017 to 2021, as they were significantly associated with resistance to ≥4 Clinical and Laboratory Standard Institute (CLSI) classes ( = 0.040 and 0.006, respectively). In conclusion, children aged <2 years old were the main pediatric burn patients with wound infections. The primary bacteria isolated from the wound were and , with a decreasing tendency of multi-resistance.

摘要

烧伤是全球儿童死亡和残疾的主要原因之一,伤口感染是烧伤治疗中的一大挑战。我们对患有伤口感染的儿科烧伤患者进行了回顾性研究,以揭示他们的临床数据,并调查病原体的分布和耐药模式,为治疗提供参考。结果,共确定了330例患有伤口感染的儿科烧伤患者;65.8%(217/330)年龄小于2岁。大多数损伤为烫伤,累及体表面积(TBSA)小于10%,主要造成二度烧伤和二度加三度烧伤。分离出359株病原体,主要病原体为(45.4%)和(18.7%)。2012年至2016年分离出的和比2017年至2021年分离出的更易产生多重耐药性,因为它们与对≥4类临床和实验室标准协会(CLSI)药物的耐药性显著相关(分别为=0.040和0.006)。总之,年龄小于2岁的儿童是患有伤口感染的主要儿科烧伤患者。从伤口分离出的主要细菌为和,多重耐药性呈下降趋势。

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