Torun Furkan M, Bilgin Halil I, Kaplan Oktay I
Rare Disease Laboratory, School of Life and Natural Sciences, Abdullah Gul University, Kayseri 38080, Turkey.
Department of Computer Engineering, Abdullah Gul University, Kayseri 38080, Turkey.
Bioinform Adv. 2021 Aug 7;1(1):vbab009. doi: 10.1093/bioadv/vbab009. eCollection 2021.
Sequence alignment is an excellent way to visualize the similarities and differences between DNA, RNA or protein sequences, yet it is currently difficult to jointly view sequence alignment data with genetic variations, modifications such as post-translational modifications and annotations (i.e. protein domains). Here, we present the MSABrowser tool that makes it easy to co-visualize genetic variations, modifications and annotations on the respective positions of amino acids or nucleotides in pairwise or multiple sequence alignments. MSABrowser is developed entirely in JavaScript and works on any modern web browser at any platform, including Linux, Mac OS X and Windows systems without any installation. MSABrowser is also freely available for the benefit of the scientific community.
MSABrowser is released as open-source and web-based software under MIT License. The visualizer, documentation, all source codes and examples are available at https://thekaplanlab.github.io/ and GitHub repository https://github.com/thekaplanlab/msabrowser.
Supplementary data are available at online.
序列比对是可视化DNA、RNA或蛋白质序列之间异同的绝佳方法，但目前很难将序列比对数据与基因变异、翻译后修饰等修饰以及注释（即蛋白质结构域）一起查看。在此，我们展示了MSABrowser工具，它能轻松地在两两比对或多序列比对中氨基酸或核苷酸的相应位置上共同可视化基因变异、修饰和注释。MSABrowser完全用JavaScript开发，可在任何平台的任何现代网络浏览器上运行，包括Linux、Mac OS X和Windows系统，无需任何安装。MSABrowser也免费提供给科学界使用。
MSABrowser作为开源的基于网络的软件，根据麻省理工学院许可发布。可视化工具、文档、所有源代码和示例可在https://thekaplanlab.github.io/ 以及GitHub仓库https://github.com/thekaplanlab/msabrowser获取。
补充数据可在网上获取。
