Translational Medical Innovation Center, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang 215600, China.
Department of Orthopedics, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang 215600, China.
Mediators Inflamm. 2023 Jan 16;2023:6331650. doi: 10.1155/2023/6331650. eCollection 2023.
Periprosthetic osteolysis (PPO), caused by wear particles, has become a major cause of joint replacement failure. Secondary surgery after joint replacement poses a serious threat to public health worldwide. Therefore, determining how to effectively inhibit wear particle-induced PPO has become an urgent issue. Recently, the interaction between osteogenic inhibition and wear particles at the biological interface of the implant has been found to be an important factor in the pathological process. Previous studies have found that the central nervous system plays an important role in the regulation of bone formation and bone remodeling. Dopamine (DA), an important catecholamine neurotransmitter, plays an integral role in the physiological and pathological processes of various tissues through its corresponding receptors. Our current study found that upregulation of dopamine first receptors could be achieved by activating the Wnt/-catenin pathway, improving osteogenesis and , and significantly reducing the inhibition of titanium particle-induced osteogenesis. Overall, these findings suggest that dopamine first receptor (D1R) may be a plausible target to promote osteoblast function and resist wear particle-induced PPO.
假体周围骨溶解（PPO）是由磨损颗粒引起的，已成为关节置换失败的主要原因。关节置换后的二次手术对全球公共健康构成了严重威胁。因此，确定如何有效抑制磨损颗粒诱导的 PPO 已成为当务之急。最近，在植入物生物界面处发现了成骨抑制与磨损颗粒之间的相互作用，这是病理过程中的一个重要因素。先前的研究发现，中枢神经系统在各种组织的生理和病理过程中发挥着重要作用。多巴胺（DA）作为一种重要的儿茶酚胺神经递质，通过其相应的受体在各种组织的生理和病理过程中发挥着重要作用。我们目前的研究发现，通过激活 Wnt/-catenin 通路可以上调多巴胺 1 型受体（D1R），改善成骨作用，并显著减少钛颗粒诱导的成骨抑制。总的来说，这些发现表明多巴胺 1 型受体（D1R）可能是促进成骨细胞功能和抵抗磨损颗粒诱导的 PPO 的一个合理靶点。
