基于聚集诱导发光分子介导的聚电解质组装体的荧光探针用于调控分子内运动和磁弛豫率
Fluorescent Probes Based on AIEgen-Mediated Polyelectrolyte Assemblies for Manipulating Intramolecular Motion and Magnetic Relaxivity.
作者信息
Yao Yongkang, Ding Peng, Yan Chenxu, Tao Yining, Peng Bo, Liu Weimin, Wang Junyou, Cohen Stuart Martien A, Guo Zhiqian
机构信息
Department Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, China.
State Key Laboratory of Chemical Engineering and Shanghai Key Laboratory of Multiphase Materials Chemical Engineering, East China University of Science and Technology, Shanghai, 200237, China.
出版信息
Angew Chem Int Ed Engl. 2023 Mar 20;62(13):e202218983. doi: 10.1002/anie.202218983. Epub 2023 Feb 10.
Uniting photothermal therapy (PTT) with magnetic resonance imaging (MRI) holds great potential in nanotheranostics. However, the extensively utilized hydrophobicity-driven assembling strategy not only restricts the intramolecular motion-induced PTT, but also blocks the interactions between MR agents and water. Herein, we report an aggregation-induced emission luminogen (AIEgen)-mediated polyelectrolyte nanoassemblies (APN) strategy, which bestows a unique "soft" inner microenvironment with good water permeability. Femtosecond transient spectra verify that APN well activates intramolecular motion from the twisted intramolecular charge transfer process. This de novo APN strategy uniting synergistically three factors (rotational motion, local motion, and hydration number) brings out high MR relaxivity. For the first time, APN strategy has successfully modulated both intramolecular motion and magnetic relaxivity, achieving fluorescence lifetime imaging of tumor spheroids and spatio-temporal MRI-guided high-efficient PTT.
将光热疗法（PTT）与磁共振成像（MRI）相结合在纳米诊疗领域具有巨大潜力。然而，广泛使用的疏水性驱动组装策略不仅限制了分子内运动诱导的光热疗法，还阻碍了磁共振剂与水之间的相互作用。在此，我们报告了一种聚集诱导发光发光体（AIEgen）介导的聚电解质纳米组装体（APN）策略，该策略赋予了独特的具有良好水渗透性的“软”内部微环境。飞秒瞬态光谱证实，APN能很好地从扭曲分子内电荷转移过程激活分子内运动。这种协同结合三个因素（旋转运动、局部运动和水合数）的全新APN策略带来了高磁共振弛豫率。首次，APN策略成功地调节了分子内运动和磁弛豫率，实现了肿瘤球体的荧光寿命成像以及时空MRI引导的高效光热疗法。
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