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评估扩展谱结合疫苗(PCV15/PCV20)在老年人中潜在获益的侵袭性肺炎球菌监测。

Invasive pneumococcal surveillance to assess the potential benefits of extended spectrum conjugate vaccines (PCV15/PCV20) in older adults.

机构信息

Department of Clinical Microbiology, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, Dublin, Ireland.

Irish Meningitis and Sepsis Reference Laboratory, Children's Health Ireland at Temple Street, Dublin, Ireland.

出版信息

Epidemiol Infect. 2023 Jan 26;151:e27. doi: 10.1017/S0950268823000110.

Abstract

The introduction of pneumococcal conjugate vaccines (PCV) into the childhood vaccination programme has reduced invasive pneumococcal disease (IPD). Although anticipated from data elsewhere, surveillance in Ireland has confirmed reductions in IPD amongst those ⩾65 years of age due to a decline of PCV serotypes in this age group. Currently, direct protection against IPD in the elderly is focused on immunisation with the 23-valent pneumococcal polysaccharide vaccine (PPV23). However, immunity may not be as effective as with PCV and, furthermore, PPV23 uptake is poor in Ireland. Hence, consideration should be given to providing a PCV to this age group.

摘要

肺炎球菌结合疫苗(PCV)引入儿童免疫规划后,侵袭性肺炎球菌病(IPD)有所减少。虽然爱尔兰的监测数据也证实了这一点,但由于该年龄组中 PCV 血清型的减少,65 岁及以上人群的 IPD 病例确实有所减少。目前,老年人预防 IPD 的直接方法是接种 23 价肺炎球菌多糖疫苗(PPV23)。然而,这种免疫效果可能不如 PCV 那么有效,此外,爱尔兰的 PPV23 接种率也很低。因此,应考虑为该年龄组提供 PCV。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7caa/9990380/8e9b073cd754/S0950268823000110_fig1.jpg

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