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巴西尿即时循环阴性质控抗原检测法诊断曼氏血吸虫病感染的准确性：一项多中心研究。

Accuracy of the urine point-of-care circulating cathodic antigen assay for diagnosing Schistosomiasis mansoni infection in Brazil: A multicenter study.

机构信息

Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Educação em Ambiente e Saúde, Rio de Janeiro, RJ, Brasil.

Universidade Federal do Ceará, Departamento de Análises Clínicas e Toxicológicas, Fortaleza, CE, Brasil.

出版信息

Rev Soc Bras Med Trop. 2023 Jan 23;56. doi: 10.1590/0037-8682-0238-2022. eCollection 2023.

DOI:10.1590/0037-8682-0238-2022
PMID:36700600
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9870275/
Abstract

BACKGROUND

The World Health Organization recommends a market-ready, urine-based point-of-care diagnostic test for circulating cathodic antigens (CCA) to determine the prevalence of S. mansoni. This study evaluated the performance of the URINE CCA (SCHISTO) ECO TESTE® (POC-ECO), which is currently available in Brazil.

METHODS

Residents from eight sites with different prevalence estimates provided one urine sample for POC-ECO and one stool sample for Kato-Katz (KK) and Helmintex® (HTX) testing as an egg-detecting reference for infection status.

RESULTS

None of the study sites had significantly higher POC-ECO accuracy than KK.

CONCLUSIONS

POC-ECO is not currently recommended in Brazilian schistosomiasis elimination programs.

摘要

背景

世界卫生组织建议使用市售的、基于尿液的即时检测诊断试验来检测循环阴转阳离子（CCA），以确定曼氏血吸虫的流行情况。本研究评估了目前在巴西可用的 URINE CCA（SCHISTO）ECO TESTE®（POC-ECO）的性能。

方法

来自八个不同流行率预估地点的居民提供一份尿液样本进行 POC-ECO 检测，以及一份粪便样本进行加藤厚涂片（KK）和 Helmintex®（HTX）检测，作为感染状况的虫卵检测参考。

结果

没有一个研究地点的 POC-ECO 检测准确性明显高于 KK。

结论

POC-ECO 目前不推荐用于巴西血吸虫病消除计划。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f58a/9870275/7dca4786cb3f/1678-9849-rsbmt-56-e0238-2022-gf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f58a/9870275/20225010564a/1678-9849-rsbmt-56-e0238-2022-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f58a/9870275/7dca4786cb3f/1678-9849-rsbmt-56-e0238-2022-gf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f58a/9870275/20225010564a/1678-9849-rsbmt-56-e0238-2022-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f58a/9870275/7dca4786cb3f/1678-9849-rsbmt-56-e0238-2022-gf2.jpg

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