通过光氧化还原 N-杂环卡宾催化的烯烃亚胺酰化反应。
Iminoacylation of Alkenes via Photoredox N-Heterocyclic Carbene Catalysis.
机构信息
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
出版信息
Org Lett. 2023 Feb 10;25(5):855-860. doi: 10.1021/acs.orglett.3c00006. Epub 2023 Jan 26.
The iminoacylation of alkenes via photoredox N-heterocyclic carbene catalysis is developed with the employment of alkene-tethered α-imino-oxy acids and acyl imidazoles. The corresponding substituted 3,4-dihydro-2-pyrroles were afforded in moderate to good yields with good to high diastereoselectivities in most cases. The reaction involves the 5--trig radical cyclization of an alkene-tethered iminyl radical and the following coupling with a ketyl radical from acyl imidazole under NHC catalysis.
通过光氧化还原 N-杂环卡宾催化烯基的亚氨基酰化作用，开发了一种使用烯基连接的α-亚氨基-氧基酸和酰基咪唑的方法。在大多数情况下，以中等至良好的收率得到相应的取代 3,4-二氢-2-吡咯，并且具有良好至高的非对映选择性。该反应涉及烯基连接的亚氨自由基的 5--三自由基环化，以及在 NHC 催化下与酰基咪唑的酮基自由基的后续偶联。
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