Department of Chemistry, Graduate School of Science, Tohoku University, Sendai, 980-8578, Japan.
Nanjing University of Information Science & Technology, Nanjing, 210044, China.
Org Lett. 2023 Feb 10;25(5):800-804. doi: 10.1021/acs.orglett.2c04307. Epub 2023 Jan 26.
A versatile synthetic method for the construction of alkylidene fluorenes and their heteroarene derivatives has been developed successfully by means of a Pd(II)-catalyzed direct C-H/C-H coupling of -alkenyl biaryls. Use of the Pd(OAc) catalyst under aerobic oxidation conditions gives rise to the corresponding alkylidene fluorenes having various functional groups and diversely fused polycyclic systems. The resulting products can serve as versatile synthetic building blocks for the construction of structurally diverse polycyclic arenes and heteroarenes.
一种通过 Pd(II)催化的 -烯基联苯的直接 C-H/C-H 偶联反应成功开发了一种用于构建亚烷基芴及其杂芳基衍生物的多功能合成方法。在有氧氧化条件下使用 Pd(OAc)催化剂会生成具有各种官能团和不同稠合多环系统的相应亚烷基芴。所得产物可用作构建结构多样的多环芳烃和杂芳烃的多功能合成砌块。
