巴西副球孢子菌对伊曲康唑敏感性降低的分离株，桃金娘科的佛罗里达杨梅、美丽奥克塔叶和诺塔奥克塔叶的乙酸乙酯提取物表现出有希望的体外活性。
Ethyl acetate fractions of Myrciaria floribunda, Ocotea pulchella, and Ocotea notata exhibit promising in vitro activity against Sporothrix brasiliensis isolates with low susceptibility to itraconazole.
机构信息
Center for Microorganisms' Investigation, Department of Microbiology and Parasitology, Biomedical Institute, Federal Fluminense University, Niterói, Alameda Barros Terra, s/nº, CEP: 24020-150, Brazil.
Laboratory of Gram Positive Cocos, Biomedical Institute, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.
出版信息
Braz J Microbiol. 2023 Mar;54(1):579-586. doi: 10.1007/s42770-023-00904-8. Epub 2023 Jan 26.
Sporothrix brasiliensis with low susceptibility isolates were described from the Brazilian zoonotic sporotrichosis hyperendemics. The aim of this work was to evaluate distinct fractions of Ocotea pulchella, Ocotea notata, Myrciaria floribunda, and Hypericum brasiliense plant extracts against itraconazole-sensitive and low susceptibility S. brasiliensis isolates. Crude extracts were tested against clinical isolates and the ATCC MYA4823 to determine the minimum inhibitory concentrations (MICs) and fungicidal or fungistatic activities (MFC). A high MICs and MFCs amplitude (1 - > 128 µg/mL) were obtained for seven extracts. The highest antimicrobial activities against sensitive S. brasiliensis were displayed by the ethyl acetate extracts of O. notata (MIC = 2-128 μg/mL) and M. floribunda (MIC = 1-8 μg/mL). A fungicidal effect was observed for all fraction extracts. Ocotea spp. and M. floribunda ethyl acetate extracts provide promising profiles against itraconazole-sensitive or low susceptibility S. brasiliensis. Future studies will determine if these extracts can contribute as alternative therapies to this neglected zoonosis.
来自巴西动物源性孢子丝菌病高度流行地区的低敏感性分离株巴西孢子丝菌被描述。本工作的目的是评估不同部位的黄皮树、心叶巴拉圭茶、草莓番石榴和巴西贯叶连翘植物提取物对敏感和低敏感性巴西孢子丝菌分离株的作用。粗提取物对临床分离株和 ATCC MYA4823 进行了测试，以确定最小抑菌浓度 (MIC) 和杀菌或抑菌活性 (MFC)。七种提取物的 MIC 和 MFC 幅度（1-128 μg/mL）较高。对敏感巴西孢子丝菌的最高抗菌活性由 O. notata（MIC = 2-128 μg/mL）和 M. floribunda（MIC = 1-8 μg/mL）的乙酸乙酯提取物显示。所有馏分提取物均显示出杀菌作用。黄皮树属和草莓番石榴的乙酸乙酯提取物对伊曲康唑敏感或低敏感性巴西孢子丝菌具有良好的应用前景。未来的研究将确定这些提取物是否可以作为替代疗法用于治疗这种被忽视的动物源性疾病。
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