Transferrin receptor 1: keeper of HFE.
作者信息
Parrow Nermi L, Fleming Robert E
机构信息
Saint Louis University School of Medicine.
出版信息
Blood. 2023 Jan 26;141(4):332-333. doi: 10.1182/blood.2022018740.
Abstract
摘要
相似文献
1
Transferrin receptor 1: keeper of HFE.转铁蛋白受体1：HFE的守护者。
Blood. 2023 Jan 26;141(4):332-333. doi: 10.1182/blood.2022018740.
2
Regulation of iron homeostasis by hepatocyte TfR1 requires HFE and contributes to hepcidin suppression in β-thalassemia.肝细胞 TfR1 通过 HFE 调节铁稳态，并有助于β地中海贫血中铁调素的抑制。
Blood. 2023 Jan 26;141(4):422-432. doi: 10.1182/blood.2022017811.
3
Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression.遗传性血色素沉着症蛋白HFE与转铁蛋白受体2的相互作用是转铁蛋白诱导的铁调素表达所必需的。
Cell Metab. 2009 Mar;9(3):217-27. doi: 10.1016/j.cmet.2009.01.010.
4
Iron homeostasis: fitting the puzzle pieces together.铁稳态：拼凑拼图碎片
Cell Metab. 2008 Apr;7(4):288-90. doi: 10.1016/j.cmet.2008.03.008.
5
HFE mRNA expression is responsive to intracellular and extracellular iron loading: short communication.HFE信使核糖核酸表达对细胞内和细胞外铁负荷有反应：简短通讯
Mol Biol Rep. 2017 Oct;44(5):399-403. doi: 10.1007/s11033-017-4123-2. Epub 2017 Aug 24.
6
Non-HFE hemochromatosis.非HFE型血色素沉着症
Semin Liver Dis. 2005 Nov;25(4):450-60. doi: 10.1055/s-2005-923316.
7
Molecular pathogenesis of hereditary hemochromatosis.遗传性血色素沉着症的分子发病机制
Histol Histopathol. 2016 Aug;31(8):833-40. doi: 10.14670/HH-11-762. Epub 2016 Mar 31.
8
Transferrin and transferrin receptors update.转铁蛋白和转铁蛋白受体更新。
Free Radic Biol Med. 2019 Mar;133:46-54. doi: 10.1016/j.freeradbiomed.2018.06.037. Epub 2018 Jun 30.
9
Regulatory networks for the control of body iron homeostasis and their dysregulation in HFE mediated hemochromatosis.控制机体铁稳态的调节网络及其在HFE介导的血色素沉着症中的失调。
J Cell Physiol. 2005 Aug;204(2):489-99. doi: 10.1002/jcp.20315.
10
Investigation of correlation between H63D and C282Y mutations in HFE gene and serum Ferritin level in beta-thalassemia major patients.重型β地中海贫血患者HFE基因H63D和C282Y突变与血清铁蛋白水平的相关性研究。
Transfus Clin Biol. 2019 Nov;26(4):249-252. doi: 10.1016/j.tracli.2019.05.003. Epub 2019 May 29.
引用本文的文献
1
Redox mechanism of glycerophospholipids and relevant targeted therapy in ferroptosis.铁死亡中甘油磷脂的氧化还原机制及相关靶向治疗
Cell Death Discov. 2025 Aug 1;11(1):358. doi: 10.1038/s41420-025-02654-y.
2
Transferrin receptors.转铁蛋白受体
Exp Mol Med. 2025 Apr;57(4):724-732. doi: 10.1038/s12276-025-01436-x. Epub 2025 Apr 22.
3
Crosstalk between ferroptosis and innate immune in diabetic kidney disease: mechanisms and therapeutic implications.糖尿病肾病中细胞铁死亡与固有免疫的相互作用：机制及治疗意义
Front Immunol. 2025 Feb 28;16:1505794. doi: 10.3389/fimmu.2025.1505794. eCollection 2025.
本文引用的文献
1
Regulation of iron homeostasis by hepatocyte TfR1 requires HFE and contributes to hepcidin suppression in β-thalassemia.肝细胞 TfR1 通过 HFE 调节铁稳态，并有助于β地中海贫血中铁调素的抑制。
Blood. 2023 Jan 26;141(4):422-432. doi: 10.1182/blood.2022017811.
2
Lobe specificity of iron binding to transferrin modulates murine erythropoiesis and iron homeostasis.铁结合到转铁蛋白的叶特异性调节小鼠红细胞生成和铁稳态。
Blood. 2019 Oct 24;134(17):1373-1384. doi: 10.1182/blood.2018893099.
3
Transferrin receptor 1 controls systemic iron homeostasis by fine-tuning hepcidin expression to hepatocellular iron load.转铁蛋白受体 1 通过精细调节铁调素表达来控制肝细胞铁负荷，从而维持全身铁稳态。
Blood. 2019 Jan 24;133(4):344-355. doi: 10.1182/blood-2018-05-850404. Epub 2018 Dec 11.
4
HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression.HFE与骨形态发生蛋白I型受体ALK3相互作用以调节铁调素的表达。
Blood. 2014 Aug 21;124(8):1335-43. doi: 10.1182/blood-2014-01-552281. Epub 2014 Jun 5.
5
Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2.转基因 HFE 依赖性小鼠铁调素的诱导不需要转铁蛋白受体-2。
Am J Hematol. 2012 Jun;87(6):588-95. doi: 10.1002/ajh.23173. Epub 2012 Mar 28.
6
Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload.小鼠中Hfe和转铁蛋白受体2的联合缺失导致铁调素显著失调和铁过载。
Hepatology. 2009 Dec;50(6):1992-2000. doi: 10.1002/hep.23198.
7
The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 cells.遗传性血色素沉着症蛋白HFE通过下调HepG2细胞中的Zip14来抑制铁摄取。
J Biol Chem. 2008 Aug 1;283(31):21462-8. doi: 10.1074/jbc.M803150200. Epub 2008 Jun 4.
8
The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression.转铁蛋白受体调节铁调素表达的Hfe依赖性调控。
Cell Metab. 2008 Mar;7(3):205-14. doi: 10.1016/j.cmet.2007.11.016.
9
Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload.小鼠肝脏转铁蛋白受体2基因的靶向破坏导致铁过载。
Gastroenterology. 2007 Jan;132(1):301-10. doi: 10.1053/j.gastro.2006.11.028. Epub 2006 Nov 18.
10
Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing.遗传性血色素沉着症蛋白HFE与转铁蛋白受体2的相互作用揭示了哺乳动物铁感应的分子机制。
J Biol Chem. 2006 Sep 29;281(39):28494-8. doi: 10.1074/jbc.C600197200. Epub 2006 Aug 7.
Zotero 插件