调制式电场热疗治疗局部晚期宫颈癌：95 例观察性研究结果。
Modulated electrohyperthermia in locally advanced cervical cancer: Results of an observational study of 95 patients.
机构信息
Department of Radiation Oncology, Jeonbuk National University Hospital, Jeonju, Republic of Korea.
Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Republic of Korea.
出版信息
Medicine (Baltimore). 2023 Jan 20;102(3):e32727. doi: 10.1097/MD.0000000000032727.
Most federation of gynecology and obstetrics stage II or higher locally advanced cervical cancer (LACC) patients are treated with concurrent chemoradiotherapy (CCRT); however, recurrence is high, and the prognosis is poor. In this observational retrospective study, data from LACC patients treated with CCRT alone or combined with modulated electrohyperthermia (mEHT) were collected from 2011 to 2018. Ninety-five LACC patients, including 53 (%) treated with CCRT alone and 42 (%) treated with CCRT + mEHT, were enrolled. The complete remission rate significantly increased with CCRT + mEHT compared with CCRT alone among LACC cases with lymph node metastasis (45% vs 71%, P = .0377). Additionally, at the last follow-up point, the no-evidence-of-disease rate significantly improved with CCRT + mEHT compared with CCRT (58% vs 82%, P = .0315). Disease-free survival increased in the CCRT + mEHT group with lymph node metastasis (P = .04). The addition of mEHT to CCRT led to a better therapeutic response in LACC with regional lymph node metastasis without severe complications.
大多数妇产科联合会 II 期或更高期局部晚期宫颈癌（LACC）患者接受同步放化疗（CCRT）治疗；然而，复发率高，预后差。在这项观察性回顾性研究中，收集了 2011 年至 2018 年期间单独接受 CCRT 或联合调制电高热疗（mEHT）治疗的 LACC 患者的数据。共纳入 95 例 LACC 患者，其中 53%（53/95）患者单独接受 CCRT 治疗，42%（42/95）患者接受 CCRT+mEHT 治疗。在伴有淋巴结转移的 LACC 患者中，与单独 CCRT 相比，CCRT+mEHT 显著提高了完全缓解率（45% vs 71%，P=.0377）。此外，在最后一次随访时，与单独 CCRT 相比，CCRT+mEHT 显著提高了无病率（58% vs 82%，P=.0315）。在伴有淋巴结转移的患者中，CCRT+mEHT 组的无病生存率提高（P=.04）。mEHT 联合 CCRT 治疗伴有区域淋巴结转移的 LACC 患者可获得更好的治疗反应，且无严重并发症。
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