Department of Herbal Pharmacology, College of Korean Medicine, Gachon University, Sujeong-gu, Seongnam, Republic of Korea.
Naturalis Inc. 6, Daewangpangyo-ro, Bundang-gu, Seongnam, Gyeonggi-do, Republic of Korea.
Medicine (Baltimore). 2023 Jan 20;102(3):e32360. doi: 10.1097/MD.0000000000032360.
Psoriasis is a chronic, inflammatory, autoimmune skin disease. The aim of this review is to systematically evaluate the efficacy and safety of integrative medicine (East Asian herbal medicine combined with conventional medicine) used to treat inflammatory skin lesions of psoriasis.
A comprehensive literature search will be conducted in 3 English databases (PubMed, Cochrane Library, and Embase), 4 Korean databases (Korean Studies Information Service System, Research Information Service System, Oriental Medicine Advanced Searching Integrated System, and Korea Citation Index), 2 Chinese databases (Chinese National Knowledge Infrastructure Database and Wanfang data), and 1 Japanese database (Citation Information by National Institute of Informatics) for randomized controlled trials from their inception until July 29, 2021. Statistical analysis will be performed using R version 4.1.2 and the R studio program using the default settings of the "meta" and "metafor" packages. The primary outcome will be an improvement in the psoriasis area severity index. All outcomes will be analyzed using a random-effects model to produce more statistically conservative results. If heterogeneity is detected in the study, the cause will be identified through sensitivity, meta-regression, and subgroup analyses. Methodological quality will be assessed independently using the revised tool for the risk of bias in randomized trials, version 2.0. The overall quality of evidence will be evaluated according to the Grading of Recommendations Assessment, Development, and Evaluation pro framework.
This study will review all available trials on the same subject and arrive at a more statistically robust conclusion based on a sufficient sample size of participants and additional analysis using data mining techniques will be performed on intervention prescription information in clinical studies collected according to rigorous criteria.
We believe that this study will provide useful knowledge on managing inflammatory skin lesions of psoriasis vulgaris using integrative medicine using East Asian herbal medicine.
银屑病是一种慢性、炎症性、自身免疫性皮肤病。本综述的目的是系统评价东亚草药结合常规药物治疗银屑病炎症性皮损的疗效和安全性。
将全面检索 3 个英文数据库（PubMed、Cochrane Library 和 Embase）、4 个韩文数据库（韩国研究信息服务系统、研究信息服务系统、东方医学高级搜索集成系统和韩国引文索引）、2 个中文数据库（中国国家知识基础设施数据库和万方数据）和 1 个日文数据库（国立信息学研究所引文信息），检索从建库到 2021 年 7 月 29 日发表的关于东亚草药联合常规药物治疗银屑病炎症性皮损的随机对照试验。使用 R 版本 4.1.2 和 R studio 程序，默认设置为“meta”和“metafor”包进行统计分析。主要结局为银屑病面积严重指数的改善。所有结局均采用随机效应模型进行分析，以产生更具统计学稳健性的结果。如果研究中存在异质性，将通过敏感性分析、荟萃回归分析和亚组分析确定原因。使用修订后的随机对照试验偏倚风险评估工具 2.0 独立评估方法学质量。根据推荐评估、制定和评估框架的 Grading of Recommendations Assessment, Development, and Evaluation 系统评估证据的总体质量。
本研究将综述同一主题的所有可用试验，并根据足够的参与者样本量和对根据严格标准收集的临床研究中干预处方信息进行数据挖掘技术的额外分析，得出更具统计学稳健性的结论。
我们相信，这项研究将为使用东亚草药治疗寻常型银屑病炎症性皮损的综合医学管理提供有用的知识。
