《因 2019 年冠状病毒病住院的老年人和痴呆症患者的临床结局：菲律宾 CORONA 研究的结果》。

Clinical Outcomes of Older Persons and Persons with Dementia Admitted for Coronavirus Disease 2019: Findings from the Philippine CORONA Study.

机构信息

Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.

Center for Memory and Cognition, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.

出版信息

Dement Geriatr Cogn Disord. 2022;51(6):485-498. doi: 10.1159/000527023. Epub 2023 Jan 26.

DOI:10.1159/000527023

PMID:36702108

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9940261/

Abstract

INTRODUCTION

The Philippine CORONA Study was a multicenter, retrospective, cohort study of 10,881 coronavirus disease 2019 (COVID-19) admissions between February and December 2020.

METHODS

Subgroup analysis was done on clinical outcomes of mortality, respiratory failure, duration of ventilator dependence, intensive care unit (ICU) admission, length of ICU stay, and length of hospital stay among older persons and persons with dementia.

RESULTS

The adjusted hazard ratios for mortality among the mild and severe cases were significantly higher by 3.93, 95% CI [2.81, 5.50] and by 1.81, 95% CI [1.43, 2.93], respectively, in older persons compared to younger adults. The adjusted hazard ratios for respiratory failure in older persons were increased by 2.65, 95% CI [1.92, 3.68] and by 1.27, 95% CI [1.01, 1.59] among the mild and severe cases, respectively. The adjusted hazard ratio for ICU admission in older persons was higher by 1.95, 95% CI [1.47, 2.59] among the mild cases. The adjusted hazard ratios for mortality and ICU admission in persons with dementia were higher by 7.25, 95% CI [2.67, 19.68] and by 4.37, 95% CI [1.08, 17.63], respectively, compared to those without dementia.

CONCLUSION

Older age and dementia significantly increased the risk of mortality, respiratory failure, and ICU admission among COVID-19 patients.

摘要

介绍

菲律宾 CORONA 研究是一项多中心、回顾性队列研究，纳入了 2020 年 2 月至 12 月期间 10881 例新型冠状病毒病 2019（COVID-19）住院患者。

方法

对死亡率、呼吸衰竭、呼吸机依赖时间、重症监护病房（ICU）入住、ICU 住院时间和住院时间等临床结局进行了亚组分析，比较了老年人和痴呆患者的临床结局。

结果

与年轻成年人相比，老年人中轻度和重度病例的死亡调整风险比分别显著升高 3.93（95%CI[2.81, 5.50]）和 1.81（95%CI[1.43, 2.93]）。老年人中轻度和重度病例的呼吸衰竭调整风险比分别升高 2.65（95%CI[1.92, 3.68]）和 1.27（95%CI[1.01, 1.59]）。老年人中轻度病例的 ICU 入住调整风险比升高 1.95（95%CI[1.47, 2.59]）。与无痴呆症患者相比，痴呆症患者的死亡率和 ICU 入住调整风险比分别升高 7.25（95%CI[2.67, 19.68]）和 4.37（95%CI[1.08, 17.63]）。