新冠病毒肺炎合并癌症患者的结局与风险因素（ONCORONA）：菲律宾CORONA研究结果

Outcomes and Risk Factors of Patients With COVID-19 and Cancer (ONCORONA): Findings from The Philippine CORONA Study.

作者信息

Espiritu Adrian I, Larrazabal Ramon B, Sy Marie Charmaine C, Villanueva Emilio Q, Anlacan Veeda Michelle M, Jamora Roland Dominic G

机构信息

Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.

Department of Clinical Epidemiology, College of Medicine, University of the Philippines Manila, Manila, Philippines.

出版信息

Front Oncol. 2022 Apr 13;12:857076. doi: 10.3389/fonc.2022.857076. eCollection 2022.

DOI:10.3389/fonc.2022.857076

PMID:35494040

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9044028/

Abstract

BACKGROUND

A study conducted in China on patients with coronavirus disease 2019 (COVID-19) showed that cancer conferred a five times increased risk for needing intensive care admission and mortality; No data has yet been collected and published from the Philippines. Thus, the investigators conducted this substudy to determine the association of having a history of cancer with clinical outcomes among patients included in the Philippine CORONA Study.

METHODOLOGY

Multi-center, retrospective cohort design.

RESULTS

A total of 244 patients had a history of cancer, out of 10,881 COVID-19 hospital admissions. After adjusting for different confounding variables of interest, having cancer was significantly associated with a 75% increased odds of having severe/critical COVID-19 at nadir (CI 95% 1.32, 2.33; < 0.001). After adjusting for different confounding variables of interest, having cancer was significantly associated with the following time-to-event outcomes: 72% increase in hazard of in-hospital mortality (CI 95% 1.37, 2.16; < 0.001), 65% increase in hazard of respiratory failure (CI 95% 1.31, 2.08; < 0.001), and 57% increase in hazard of being admitted to ICU (CI 95% 1.24, 1.97; < 0.001).

CONCLUSION

A history of cancer conferred poorer clinical outcomes on adult, hospitalized COVID-19 patients.

摘要

背景

在中国针对2019冠状病毒病（COVID-19）患者开展的一项研究表明，癌症使重症监护入院需求和死亡风险增加了五倍；菲律宾尚未收集并发表相关数据。因此，研究人员开展了这项子研究，以确定在菲律宾冠状病毒研究纳入的患者中，癌症病史与临床结局之间的关联。

方法

多中心回顾性队列设计。

结果

在10881例COVID-19住院患者中，共有244例有癌症病史。在对不同的相关混杂变量进行调整后，患癌症与最低点时出现重症/危重症COVID-19的几率显著增加75%相关（95%置信区间1.32, 2.33；<0.001）。在对不同的相关混杂变量进行调整后，患癌症与以下事件发生时间结局显著相关：院内死亡风险增加72%（95%置信区间1.37, 2.16；<0.001），呼吸衰竭风险增加65%（95%置信区间1.31, 2.08；<0.001），以及入住重症监护病房风险增加57%（95%置信区间1.24, 1.97；<0.001）。