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生命末期的精神幸福感、与尊严相关的痛苦和道德低落-尊严疗法的效果:一项随机对照试验。

Spiritual well-being, dignity-related distress and demoralisation at the end of life-effects of dignity therapy: a randomised controlled trial.

机构信息

Department of Human Sciences, European University of Rome, Rome, Italy

U.O. di Cure Palliative, Fondazione Sanità e Ricerca, Rome, Italy.

出版信息

BMJ Support Palliat Care. 2024 Jan 8;13(e3):e1238-e1248. doi: 10.1136/spcare-2022-003696.

Abstract

OBJECTIVES

This single-centre prospective randomised controlled study aimed to investigate the effectiveness of dignity therapy on spiritual well-being, demoralisation and dignity-related distress compared with standard palliative care.

METHODS

A total of 111 terminally ill hospice patients were randomly allocated to one of two groups: dignity therapy plus standard palliative care (intervention group) or standard palliative care alone (control group). The main outcomes were meaning, peace, faith, loss of meaning and purpose, distress and coping ability, existential distress, psychological distress and physical distress. Assessments were conducted at baseline, 7-10 and 15-20 days.

RESULTS

Following randomisation, 11 dropped out before baseline assessment and 33 after post-treatment assessment. A total of 67 patients completed the study, 35 in the experimental group and 32 in the control group. Repeated measures general linear model showed significant differences between groups on peace and psychological distress over time, but not on existential distress, physical distress, meaning and purpose, distress and coping ability, meaning and faith. Specifically, patients in the dignity therapy intervention maintained similar levels of peace from baseline to follow-up, whereas patients in the control group significantly declined in peace during the same time period. Moreover, psychological distress significantly decreased from pretreatment to post-treatment in the intervention group and increased in the control group.

CONCLUSIONS

Dignity therapy may be an effective intervention in maintaining sense of peace for terminally ill patients. The findings of our study are of relevance in palliative care and suggest the potential clinical utility of this psychological intervention.

摘要

目的

本单中心前瞻性随机对照研究旨在比较尊严疗法与标准姑息治疗对精神幸福感、道德困境和与尊严相关的痛苦的疗效。

方法

共纳入 111 例终末期 Hospice 患者,随机分为两组:尊严疗法加标准姑息治疗(干预组)或标准姑息治疗(对照组)。主要结局为意义、平静、信念、意义和目的丧失、痛苦和应对能力、存在性痛苦、心理痛苦和身体痛苦。评估在基线、7-10 天和 15-20 天进行。

结果

随机分组后,11 例患者在基线评估前退出,33 例患者在治疗后评估后退出。共有 67 例患者完成了研究,实验组 35 例,对照组 32 例。重复测量的一般线性模型显示,组间在平静和心理痛苦方面随时间有显著差异,但在存在性痛苦、身体痛苦、意义和目的、痛苦和应对能力、意义和信念方面无显著差异。具体而言,尊严疗法干预组患者的平静水平从基线到随访期间保持相似,而对照组患者在同一时间段内明显下降。此外,干预组患者的心理痛苦从治疗前到治疗后显著下降,而对照组患者的心理痛苦则增加。

结论

尊严疗法可能是一种有效的干预措施,可维持终末期患者的平静感。本研究结果在姑息治疗中具有相关性,并提示这种心理干预具有潜在的临床应用价值。

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