Eldeeb Mohamed A, Zorca Cornelia E, Goiran Thomas
Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Commun Chem. 2020 Oct 30;3(1):149. doi: 10.1038/s42004-020-00397-8.
Tight regulation of protein levels is so crucial for cellular function that mammalian cells have evolved two parallel degradation systems. This article discusses how these systems can be exploited to selectively target proteins of interest for therapeutic purposes.
蛋白质水平的严格调控对于细胞功能至关重要，以至于哺乳动物细胞进化出了两个平行的降解系统。本文讨论了如何利用这些系统来选择性地靶向感兴趣的蛋白质以用于治疗目的。
