Iwakura Izumi, Komori-Orisaku Keiko, Hashimoto Sena, Akai Shoji, Kimura Kenta, Yabushita Atsushi
Department of Chemistry, Faculty of Engineering, Kanagawa University, 3-27-1 Rokkakubashi, Yokohama, 221-8686, Japan.
Research Institute of Engineering, Kanagawa University, 3-27-1 Rokkakubashi, Yokohama, 221-8686, Japan.
Commun Chem. 2020 Mar 17;3(1):35. doi: 10.1038/s42004-020-0281-6.
Compound crystallization is typically achieved from supersaturated solutions over time, through melting, or via sublimation. Here a new method to generate a single crystal of thioglucoside using a sub-10-fs pulse laser is presented. By focusing the laser pulse on a solution in a glass cell, a single crystal is deposited at the edge of the ceiling of the glass cell. This finding contrasts other non-photochemical laser-induced nucleation studies, which report that the nucleation sites are in the solution or at the air-solution interface, implying the present crystallization mechanism is different. Irradiation with the sub-10-fs laser pulse does not heat the solution but excites coherent molecular vibrations that evaporate the solution. Then, the evaporated solution is thought to be deposited on the glass wall. This method can form crystals even from unsaturated solutions, and the formed crystal does not include any solvent, allowing the formation of a pure crystal suitable for structural analysis, even from a minute amount of sample solution.
化合物结晶通常随着时间的推移，通过熔融或升华从过饱和溶液中实现。本文提出了一种使用亚10飞秒脉冲激光生成硫代葡萄糖苷单晶的新方法。通过将激光脉冲聚焦在玻璃池中的溶液上，在玻璃池顶部边缘沉积出单晶。这一发现与其他非光化学激光诱导成核研究形成对比，其他研究报告成核位点在溶液中或气-液界面处，这意味着当前的结晶机制不同。用亚10飞秒激光脉冲照射不会加热溶液，而是激发相干分子振动使溶液蒸发。然后，蒸发的溶液被认为沉积在玻璃壁上。该方法甚至可以从不饱和溶液中形成晶体，并且形成的晶体不包含任何溶剂，即使从微量的样品溶液中也能形成适合结构分析的纯晶体。
