Weng Yue, Song Chunlan, Chiang Chien-Wei, Lei Aiwen
Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecule & School of Chemistry and Chemical Engineering, Hubei University, 430062, Wuhan, Hubei, China.
College of Chemistry and Molecular Sciences, Wuhan University, 430072, Wuhan, Hubei, China.
Commun Chem. 2020 Nov 13;3(1):171. doi: 10.1038/s42004-020-00413-x.
Bioconjugation reactions play a central facilitating role in engendering modified peptides and proteins. Early progress in this area was inhibited by challenges such as the limited range of substrates and the relatively poor biocompatibility of bioconjugation reagents. However, the recent developments in visible-light induced photoredox catalysis and electrochemical catalysis reactions have permitted significant novel reactivities to be developed in the field of synthetic and bioconjugation chemistry. This perspective describes recent advances in the use of biocompatible energy input for the modification of peptides and proteins mainly, via the single electron transfer (SET) process, as well as key future developments in this area.
生物共轭反应在生成修饰肽和蛋白质方面发挥着核心促进作用。该领域的早期进展受到诸如底物范围有限和生物共轭试剂生物相容性相对较差等挑战的抑制。然而，可见光诱导的光氧化还原催化和电化学催化反应的最新进展使得合成和生物共轭化学领域能够开发出显著的新型反应活性。本综述主要描述了利用生物相容性能量输入通过单电子转移（SET）过程修饰肽和蛋白质的最新进展，以及该领域未来的关键发展。
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