Antonio Pereira Isabela, Judah Cury Benhur, Kaio Silva Nunes Ruan, Mota da Silva Luisa
Nursing Course., University of Vale do Itajaí - UNIVALI, Itajaí, Brazil.
Postgraduate Program in Pharmaceutical Sciences, University of Vale do Itajaí-UNIVALI, Itajaí, Brazil.
Chem Biodivers. 2023 Feb;20(2):e202201021. doi: 10.1002/cbdv.202201021. Epub 2023 Jan 26.
In southern Brazil, the biodiversity is great and the traditional use of medicinal plants for wound healing has been documented in ethnobotanical studies and pharmacological studies have assessed their wound properties and phytochemistry. Therefore, this study evaluated ethnobotanical surveys regarding medicinal plants used in southern Brazil for wound healing and studies about the healing properties of these plants published between 2000 and 2022. To retrieve articles related to the study, Web of Science, PubMed (NLM), Open Access Journals, Scielo, Lilacs, and Google Scholar, with keywords including medicinal plants, wound healing, and South of Brazil, have been used. As a result, 73 medicinal plants belonging to 39 families were found in ethnobotanical surveys as a traditional resource used for wound healing in southern Brazil, 15 of which were cited more than once. Besides, 14 of these 15 plants were also used as healing agents worldwide. The most cited plant with healing actions in southern Brazil was Symphytum officinale L. (comfrey). From 2000 to date, 44 articles scientifically demonstrated the wound-healing effects of the southern Brazilian plants found in ethnobotanical surveys reviewed. The folk medicine of southern Brazil presents a variety of medicinal plants for wound-healing purposes, and scientific data were found for some of those plants. However, the wound-healing properties of many plants have yet to be investigated, and the current literature still needs more phytochemical information about the plants studied. Aside from this, the future focus should be on the standardization of herbal extracts, and further research is required to investigate the pharmacological mechanisms. Clinical research in this area remains in its infancy and warrants more robust further clinical studies.
在巴西南部，生物多样性丰富，民族植物学研究记录了当地传统上使用药用植物治疗伤口的情况，药理学研究也评估了这些植物的伤口愈合特性及其植物化学性质。因此，本研究评估了关于巴西南部用于伤口愈合的药用植物的民族植物学调查，以及2000年至2022年间发表的有关这些植物愈合特性的研究。为了检索与该研究相关的文章，使用了科学网、PubMed（美国国立医学图书馆）、开放获取期刊、Scielo、Lilacs和谷歌学术，关键词包括药用植物、伤口愈合和巴西南部。结果，在民族植物学调查中发现，有73种属于39个科的药用植物是巴西南部用于伤口愈合的传统资源，其中15种被多次提及。此外，这15种植物中有14种在全球范围内也被用作治疗剂。在巴西南部最常被提及具有愈合作用的植物是药用紫草（聚合草）。从2000年至今，有44篇文章科学地证明了在民族植物学调查中发现的巴西南部植物的伤口愈合效果。巴西南部的民间医学中有多种用于伤口愈合的药用植物，并且为其中一些植物找到了科学数据。然而，许多植物的伤口愈合特性尚未得到研究，目前的文献仍然需要更多关于所研究植物的植物化学信息。除此之外，未来的重点应该是草药提取物的标准化，并且需要进一步研究来探究其药理机制。该领域的临床研究仍处于起步阶段，值得开展更有力的进一步临床研究。
