Department of Occupational and Environmental Medicine, Inje University Haeundae Paik Hospital, 875 Haeun-daero, Haeundae-gu, Busan, 48108, South Korea.
Sci Rep. 2024 Mar 29;14(1):7511. doi: 10.1038/s41598-024-58263-9.
Polycyclic aromatic hydrocarbons (PAHs) are widespread pollutants associated with several adverse health effects and PAH-induced oxidative stress has been proposed as a potential mechanism. This study evaluated the associations of single and multiple PAHs exposure with oxidative stress within the Korean adult population, using serum gamma glutamyltransferase (GGT) as an oxidative stress marker. Data from the Second Korean National Environmental Health Survey (2012-2014) were analyzed. For analysis, 5225 individuals were included. PAH exposure was assessed with four urinary PAH metabolites: 1-hydroxyphenanthrene, 1-hydroxypyrene, 2-hydroxyfluorene, and 2-naphthol. After adjusting for age, sex, body mass index, drinking, passive smoking, and current smoking (model 1), as well as the presence of diabetes and hepatobiliary diseases (model 2), complex samples general linear model regression analyses for each metabolite revealed a significant positive association between Ln(1-hydroxyphenanthrene) and Ln(GGT) (model 1: β = 0.040, p < 0.01 and model 2: β = 0.044, p < 0.05). For the complete dataset (n = 4378), a significant positive association was observed between mixture of four urinary PAH metabolites and serum GGT in both the quantile g-computation and the Bayesian kernel machine regression analysis. Our study provides evidence for the association between mixed PAH exposure and oxidative stress.
多环芳烃（PAHs）是广泛存在的污染物，与多种健康不良影响有关，并且已经提出 PAH 诱导的氧化应激是一种潜在的机制。本研究使用血清γ-谷氨酰转移酶（GGT）作为氧化应激标志物，评估了韩国成年人群中单一和多种 PAH 暴露与氧化应激的关联。使用了来自 2012-2014 年韩国第二次国家环境健康调查的数据进行分析。在分析中，纳入了 5225 个人。使用四种尿液 PAH 代谢物来评估 PAH 暴露：1-羟基菲、1-羟基芘、2-羟基芴和 2-萘酚。在调整了年龄、性别、体重指数、饮酒、被动吸烟和当前吸烟（模型 1）以及糖尿病和肝胆疾病的存在（模型 2）后，对每种代谢物进行复杂样本一般线性模型回归分析显示，Ln(1-羟基菲)与 Ln(GGT)之间存在显著正相关（模型 1：β=0.040，p<0.01；模型 2：β=0.044，p<0.05）。对于完整数据集（n=4378），在分位数 g 计算和贝叶斯核机器回归分析中，均观察到四种尿液 PAH 代谢物混合物与血清 GGT 之间存在显著正相关。本研究为混合 PAH 暴露与氧化应激之间的关联提供了证据。
