Department of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Anesthesiology and Critical Care Medicine Key Laboratory of Luzhou, Southwest Medical University, Luzhou, China.
Ann Clin Transl Neurol. 2023 Apr;10(4):497-506. doi: 10.1002/acn3.51740. Epub 2023 Jan 27.
To evaluate the effect of overall peripheral inflammatory levels on cognitive function, we explored the relationship between established biomarkers of peripheral inflammation (circulating C-reactive protein [CRP], interleukin-6 [IL-6], and tumor necrosis factor-α [TNF-α]) and cognitive decline by performing a review of observational studies and creating an updated summary.
We included literatures exploring the relationship between peripheral levels of CRP, IL-6, and TNF-α and subsequent cognitive decline, published until July 2022, by searching the following databases: PubMed, Embase, Web of Science, the Cochrane Library, ClinicalTrials, CNKI, and VIP databases. We used random-effects models to pool the odds ratios (ORs) for the risks of subsequent cognitive decline in older adults with high levels of peripheral inflammation. We initially screened out 501 literatures, of which only 17 were ultimately eligible. Overall, there were 19,516 older individuals included in our meta-analysis, and 2134 of them experienced subsequent cognitive change.
Individuals with high levels of peripheral inflammation may have 14% more chance to develop subsequent cognitive decline than those with low levels (OR = 1.14, 95% CI: 1.03-1.27; p < 0.00001). In the subgroup analysis, the incidence of cognitive decline was higher in individuals with high levels of IL-6. This study further demonstrates the link between systemic inflammation and cognitive status.
Detecting CRP, IL-6, and TNF-α in peripheral blood is necessary, as they may become effective indicators for forthcoming cognitive performance.
为了评估整体外周炎症水平对认知功能的影响，我们通过综述观察性研究并进行更新汇总，探讨了外周炎症的既定生物标志物（循环 C 反应蛋白 [CRP]、白细胞介素-6 [IL-6]和肿瘤坏死因子-α [TNF-α]）与认知能力下降之间的关系。
我们纳入了探索 CRP、IL-6 和 TNF-α 外周水平与老年人随后认知能力下降之间关系的文献，检索时间截至 2022 年 7 月，检索数据库包括 PubMed、Embase、Web of Science、Cochrane 图书馆、ClinicalTrials、CNKI 和 VIP 数据库。我们使用随机效应模型汇总外周炎症水平较高的老年人发生后续认知衰退风险的比值比（OR）。我们最初筛选出 501 篇文献，其中只有 17 篇最终符合纳入标准。总的来说，我们的荟萃分析纳入了 19516 名老年人，其中 2134 人发生了随后的认知变化。
与低水平炎症相比，高水平外周炎症的个体发生后续认知衰退的可能性增加 14%（OR=1.14，95%CI：1.03-1.27；p<0.00001）。在亚组分析中，高水平 IL-6 的个体认知衰退发生率更高。这项研究进一步证明了全身炎症与认知状态之间的联系。
检测外周血中的 CRP、IL-6 和 TNF-α 是必要的，因为它们可能成为未来认知表现的有效指标。
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