Yamashita K, Iwamoto T, Iijima S
Acta Pathol Jpn. 1978 Sep;28(5):697-703. doi: 10.1111/j.1440-1827.1978.tb00909.x.
Lysozyme activities of skin granulomas of 24 patients in leprosy were studied. Lepra cells of all 15 lepromatous leprosy showed strong lysozyme activity in cytoplasma. In the specimens stained with lysozyme and Ziehl-Neelsen's carbolfuchsin double stain conspicuous lysozyme activity around M. leprae were observed. One borderline case was negative. Lysozyme of epithelioid cells and giant cells of 10 tuberculoid types were completely negative. These results suggest that lysozyme plays only a small role in the disposal of M. leprae in macrophages and other mechanisms than bacteriolytic function of lysozyme are responsible for the defence against these bacilli.
对24例麻风患者皮肤肉芽肿的溶菌酶活性进行了研究。15例瘤型麻风的麻风细胞在胞质中均显示出较强的溶菌酶活性。在用溶菌酶和萋-尼氏石炭酸复红双重染色的标本中，观察到麻风杆菌周围有明显的溶菌酶活性。1例界线类病例为阴性。10例结核样型的上皮样细胞和巨细胞的溶菌酶完全阴性。这些结果表明，溶菌酶在巨噬细胞中对麻风杆菌的清除中仅起很小的作用，除溶菌酶的溶菌功能外，其他机制负责对这些杆菌的防御。
