Gasparova Zdenka, Ruskova Euridika, Seckarova Michalikova Dominika, Brnoliakova Zuzana, Svik Karol, Slovak Lukas, Bezek Stefan, Knezl Vladimir, Sotnikova Ruzena
Centre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Bratislava, Slovakia.
Gen Physiol Biophys. 2023 Jan;42(1):25-36. doi: 10.4149/gpb_2022053.
A high-fructose intake is metabolically analogous to a high-fat diet. The impact of highfructose intake was investigated in spontaneously hypertensive (SHR) and hypertriacylglycerolemic (HTG) rats to find out the impact of which risk factor of metabolic syndrome - hypertension or hypertriacylglycerolemia - will cause more complications. Rats were fed a standard or a fructose diet (F60) with 60% of added fructose for 5 weeks. The F60 diet increased the total serum cholesterol content of both HTG-F60 and SHR-F60 rats. Further, in SHR-F60 it increased serum triacylglycerols, TBARS in the liver, a specific activity of NAGA in the kidney, aggravated glucose tolerance, deteriorated synaptic plasticity, and reduced somatic and dendritic responses in the hippocampus. SHR rats were more sensitive to the F60 diet, suggesting that hypertension along with a high-fructose intake result in a more pronounced disorder compared to hypertriacylglycerolemia. This work wants to draw attention to fructose-induced health risks associated with hypertension.
高果糖摄入在代谢方面与高脂肪饮食类似。在自发性高血压（SHR）大鼠和高三酰甘油血症（HTG）大鼠中研究了高果糖摄入的影响，以确定代谢综合征的哪个危险因素——高血压或高三酰甘油血症——会导致更多并发症。给大鼠喂食标准饮食或含60%添加果糖的果糖饮食（F60），持续5周。F60饮食增加了HTG - F60和SHR - F60大鼠的血清总胆固醇含量。此外，在SHR - F60大鼠中，它增加了血清三酰甘油、肝脏中的硫代巴比妥酸反应物（TBARS）、肾脏中N - 乙酰 - β - D - 氨基葡萄糖苷酶（NAGA）的比活性，加重了葡萄糖耐量，使突触可塑性恶化，并降低了海马体中的躯体和树突反应。SHR大鼠对F60饮食更敏感，这表明与高三酰甘油血症相比，高血压与高果糖摄入一起会导致更明显的紊乱。这项研究旨在引起人们对与高血压相关的果糖诱导的健康风险的关注。
