Diagnostic accuracy of shear wave elastography for endometrial cancer: A meta-analysis.

BACKGROUND

This meta-analysis aimed to identify the accuracy of shear wave elastography (SWE) in the diagnosis of endometrial cancer (EC).

METHODS

We searched the PubMed, Cochrane Library, and chinese biomedical literature database from inception to September 30, 2022. Meta-analysis was conducted using STATA version 14.0 and Meta-Disc version 1.4 software. We calculated summary statistics for sensitivity (Sen), specificity (Spe), positive and negative likelihood ratio (LR+/LR-), diagnostic odds ratio (DOR), and receiver operating characteristic (SROC) curves.

RESULTS

Eight studies that met all the inclusion criteria were included in this meta-analysis. A total of 432 patients with EC and 548 with benign endometrial lesions were assessed. All endometrial lesions were histologically confirmed by SWE. The pooled Sen was 0.91 (95% confidence interval [CI] = 0.83-0.95); the pooled Spe was 0.90 (95% CI = 0.86-0.93); the pooled LR+ was 9.10 (95% CI = 6.20-13.35); the pooled negative LR- was 0.10 (95% CI = 0.05-0.20); the pooled DOR of SWE in the diagnosis of EC was 90.73 (95% CI = 36.62-804.5). The area under the SROC curve was 0.95 (95% CI = 0.93-0.97). No evidence of publication bias was found (t = 0.98, P = .37).

CONCLUSION

Our meta-analysis indicates that SWE may have high diagnostic accuracy in the differential diagnosis of benign and malignant endometrial lesions. Thus, SWE may be a useful tool for the diagnosis of EC.