Hinson J P, Vinson G P, Porter I D, Whitehouse B J
Department of Biochemistry, Medical College of St Bartholomew's Hospital, London.
Neuropeptides. 1987 Jul;10(1):1-7. doi: 10.1016/0143-4179(87)90083-7.
Using the intact isolated perfused rat adrenal preparation we have shown for the first time a direct effect of oxytocin on adrenocortical steroid secretion. Oxytocin specifically stimulated aldosterone secretion in a dose-dependent manner with a threshold dose of 1 pmol. Arginine vasopressin was also shown to be a potent stimulus to aldosterone secretion and was additionally found to stimulate inner zone function. Using superfused adrenal cells, the effects of arginine vasopressin were only seen at 10,000 times higher doses than were effective in the intact perfused gland, and oxytocin had no effect at any dose. These results reinforce the hypothesis that tissue integrity is essential for full expression of steroidogenic control mechanisms. We conclude that oxytocin and vasopressin may play a role in the control of steroidogenesis.
利用完整的离体灌注大鼠肾上腺制备物，我们首次证明了催产素对肾上腺皮质类固醇分泌有直接作用。催产素以剂量依赖的方式特异性刺激醛固酮分泌，阈剂量为1皮摩尔。精氨酸加压素也被证明是醛固酮分泌的有效刺激物，此外还发现它能刺激肾上腺内层功能。使用灌流肾上腺细胞时，精氨酸加压素的作用仅在比完整灌注腺体有效剂量高10000倍时才可见，而催产素在任何剂量下均无作用。这些结果强化了这样一种假说，即组织完整性对于类固醇生成控制机制的充分表达至关重要。我们得出结论，催产素和加压素可能在类固醇生成的控制中发挥作用。
