Senn M, Maier P M, Langhans W
Institute for Animal Sciences, Swiss Federal Institute of Technology, Zurich.
J Comp Physiol B. 1995;164(7):570-8. doi: 10.1007/BF00261398.
The present study compared the effects of vasopressin on plasma concentrations of corticotropin, cortisol and glucose in cattle and sheep. After intravenous injection of 1, 0.1 and 0.01 microgram vasopressin per kg body weight, the plasma vasopressin concentration increased proportionally to the injected dose, and this increase was similar in cattle and sheep. Doses of 1 and 0.1 microgram per kg body weight of vasopressin triggered significant responses of corticotropin, cortisol and glucose in cattle and sheep. The corticotropin response to both doses was significantly greater in sheep, whereas the glucose response was greater in cattle. The cortisol response did not differ between species. The lowest dose of vasopressin (0.01 microgram per kg body weight) still induced a significant cortisol response without a substantial effect on plasma corticotropin, suggesting that a direct action of vasopressin on the adrenals may contribute to the observed cortisol response. The results demonstrate that vasopressin increases plasma levels of corticotropin, cortisol and glucose in cattle, as it does in sheep, but the intensities of the corticotropin and glucose responses to vasopressin differ between cattle and sheep. The reasons for these differences remain to be clarified.
本研究比较了血管升压素对牛和羊血浆中促肾上腺皮质激素、皮质醇和葡萄糖浓度的影响。静脉注射每千克体重1、0.1和0.01微克血管升压素后，血浆血管升压素浓度与注射剂量成比例增加，且牛和羊的这种增加相似。每千克体重1和0.1微克剂量的血管升压素引发了牛和羊体内促肾上腺皮质激素、皮质醇和葡萄糖的显著反应。绵羊对这两种剂量的促肾上腺皮质激素反应显著更大，而牛的葡萄糖反应更大。不同物种间的皮质醇反应没有差异。最低剂量的血管升压素（每千克体重0.01微克）仍能诱导显著的皮质醇反应，而对血浆促肾上腺皮质激素没有实质性影响，这表明血管升压素对肾上腺的直接作用可能导致了观察到的皮质醇反应。结果表明，血管升压素在牛体内会像在羊体内一样增加血浆中促肾上腺皮质激素、皮质醇和葡萄糖的水平，但牛和羊对血管升压素的促肾上腺皮质激素和葡萄糖反应强度有所不同。这些差异的原因仍有待阐明。
