Simon David Aaron, Kellermayer Richard
From the Division of Pediatric Gastroenterology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX.
the USDA/ARS Children's Nutrition Research Center, Houston, TX.
J Pediatr Gastroenterol Nutr. 2023 Feb 1;76(2):123-127. doi: 10.1097/MPG.0000000000003664. Epub 2022 Nov 23.
The microbiome is known to play an important role in the development and maintenance of human health. During early childhood the gut microbiome undergoes a rapid evolution, making this developmental window most susceptible to microbial manipulation and, therefore, most vulnerable to environmental stimuli. Such stimuli may induce persistent alterations (or dysbiosis) in microbiome and/or host physiology, thereby resulting in susceptibility to subsequent disease development. This phenomenon is frequently described as "the microbial developmental origins of disease." In this topic of the month, we call attention to the microbial developmental origins of disease by examining the potential for childhood antibiotic exposures and appendectomy (ie, inducers of dysbiosis) to influence the pathogenesis of certain multifactorial, common diseases (eg, celiac disease, inflammatory bowel disease, obesity), especially those with increasing incidence worldwide. We conclude that fully appreciating the critical components in the microbial developmental origins of common chronic disorders is a major task ahead of pediatric gastroenterologists in the 21st century. Such information will be key in working to prevent numerous common and emerging disorders.
众所周知，微生物群在人类健康的发展和维持中起着重要作用。在幼儿期，肠道微生物群会经历快速演变，使得这个发育阶段最容易受到微生物调控的影响，因此也最容易受到环境刺激的影响。此类刺激可能会诱发微生物群和/或宿主生理的持续改变（或失调），从而导致对后续疾病发展的易感性。这种现象通常被描述为“疾病的微生物发育起源”。在本月的这个专题中，我们通过研究儿童期抗生素暴露和阑尾切除术（即失调诱导因素）影响某些多因素常见疾病（如乳糜泻、炎症性肠病、肥胖症）发病机制的可能性，尤其是那些在全球发病率不断上升的疾病，来关注疾病的微生物发育起源。我们得出结论，充分认识常见慢性疾病微生物发育起源中的关键因素是21世纪儿科胃肠病学家面临的一项主要任务。此类信息对于预防众多常见和新出现的疾病至关重要。
