Dunedin Hospital, 201 Great King Street, Dunedin 9016, New Zealand.
Department of Pathology, Dunedin School of Medicine, University of Otago, PO Box 56, Dunedin 9054, New Zealand.
PET Clin. 2023 Apr;18(2):161-168. doi: 10.1016/j.cpet.2022.10.002. Epub 2023 Jan 25.
Neuroendocrine tumors have variety of biological and clinical characteristics. The classification of neuroendocrine neoplasm has evolved, and the newest 2019 World Health Organization classification outlines a well-differentiated high-grade G3 subtype, recognizing its differences from the poorly differentiated neuroendocrine carcinoma. Ga-DOTAT PET has largely replaced somatostatin scintigraphy as the diagnostic workup choice for NENs. NETest, a multi-analyte liquid biopsy, is a promising recent development in the biochemical diagnosis. Management includes wait and watch approach, surgical resection, somatostatin analogs, Lu DOTATATE therapy, chemotherapy, radiotherapy or immunotherapy combinations. Further clinical trials are necessary for determining the appropriate sequencing.
神经内分泌肿瘤具有多种生物学和临床特征。神经内分泌肿瘤的分类已经发展，最新的 2019 年世界卫生组织分类概述了一种分化良好的高级别 G3 亚型，认识到它与分化不良的神经内分泌癌的不同。Ga-DOTAT PET 已在很大程度上取代了生长抑素闪烁显像，成为神经内分泌肿瘤的诊断选择。NETest 是一种多分析物液体活检，是生化诊断方面的一项有前途的最新进展。治疗包括等待观察、手术切除、生长抑素类似物、Lu DOTATATE 治疗、化疗、放疗或免疫治疗联合。需要进一步的临床试验来确定适当的治疗顺序。
