Department of Hepatology and Gastroenterology, Charité University Medicine Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Clinic for Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University Düsseldorf, Moorenstrasse 5, 40225, Düsseldorf, Germany.
J Cancer Res Clin Oncol. 2023 Aug;149(10):7557-7563. doi: 10.1007/s00432-023-04711-4. Epub 2023 Mar 27.
Previous studies have found variations in cancer types, tumor progression, and disease outcomes between men and women. However, there is limited knowledge of the effect of sex on gastrointestinal neuroendocrine neoplasms (GI-NENs).
We identified 1354 patients with GI-NEN from the IQVIA's Oncology Dynamics database. Patients were derived from four European countries (Germany, France, the United Kingdom (UK), Spain). Clinical and tumor related characteristics including patients' age, tumor stage, tumor grading and differentiation, frequency and sites of metastases, as well as co-morbidities were analyzed as a function of patients´ sex.
Among the 1354 included patients, 626 were female and 728 were male. The median age was similar between both groups (w: 65.6 years, SD: 12.1 vs. m: 64.7 years; SD: 11.9; p = 0.452). UK was the country with the most patients, however, there was no differences in the sex ratio between the different countries. Among documented co-morbidities, asthma was more often diagnosed in women (7.7% vs. 3.7%), while COPD was more prevalent in men (12.1% vs. 5.8%). The ECOG performance states was comparable between females and males. Of note, the patients´ sex was not associated with tumor origin (e.g., pNET or siNET). Females were overrepresented among G1 tumors (22.4% vs. 16.8%), however, median proliferation rates according to Ki-67 were similar between both groups. In line, no differences in tumor stages was found and rates of metastases as well as the specific sites of metastases were similar between males and females. Finally, no differences in the applied tumor specific treatments between the both sexes became apparent.
Females were overrepresented among G1 tumors. No further sex-specific differences became apparent, highlighting that sex-related factors might play a rather subordinate role in the pathophysiology of GI-NENs. Such data may help to better understand the specific epidemiology of GI-NEN.
先前的研究发现男性和女性之间的癌症类型、肿瘤进展和疾病结局存在差异。然而，关于性别对胃肠道神经内分泌肿瘤（GI-NENs）的影响知之甚少。
我们从 IQVIA 的肿瘤动力学数据库中确定了 1354 名 GI-NEN 患者。这些患者来自四个欧洲国家（德国、法国、英国（UK）和西班牙）。我们分析了包括患者年龄、肿瘤分期、肿瘤分级和分化、转移频率和部位以及合并症在内的临床和肿瘤相关特征，作为患者性别函数的一部分。
在纳入的 1354 名患者中，626 名为女性，728 名为男性。两组患者的中位年龄相似（女性：65.6 岁，SD：12.1；男性：64.7 岁，SD：11.9；p=0.452）。英国是患者人数最多的国家，但不同国家之间的性别比例没有差异。在记录的合并症中，女性更常被诊断为哮喘（7.7%比 3.7%），而男性更常被诊断为 COPD（12.1%比 5.8%）。女性和男性的 ECOG 表现状态相似。值得注意的是，患者的性别与肿瘤起源无关（例如 pNET 或 siNET）。G1 肿瘤中女性比例较高（22.4%比 16.8%），但两组之间根据 Ki-67 计算的增殖率相似。同样，两组之间的肿瘤分期没有差异，转移率以及转移的具体部位也相似。最后，两种性别之间的肿瘤特异性治疗应用也没有差异。
G1 肿瘤中女性比例较高。没有发现其他性别特异性差异，这突出表明性别相关因素在 GI-NEN 的病理生理学中可能发挥次要作用。这些数据可能有助于更好地了解 GI-NEN 的特定流行病学。
