文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

m6A 阅读器 YTHDF1 在泛癌中作为诊断生物标志物的潜在作用以及肿瘤发生和转移中的信号通路。

The potential role of m6A reader YTHDF1 as diagnostic biomarker and the signaling pathways in tumorigenesis and metastasis in pan-cancer.

作者信息

Zhu Yanan, Li Jing, Yang Hang, Yang Xinyi, Zhang Ya, Yu Xinchao, Li Ying, Chen Gangxian, Yang Zuozhang

机构信息

Bone and Soft Tissue Tumors Research Centre of Yunnan Province, Department of Orthopaedics, The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital), 650118, Kunming, Yunnan, China.

Department of Rehabilitation Medicine, The Second Affiliated Hospital of Kunming Medical University, 650106, Kunming, Yunnan, China.

出版信息

Cell Death Discov. 2023 Jan 28;9(1):34. doi: 10.1038/s41420-023-01321-4.

DOI:10.1038/s41420-023-01321-4
PMID:36707507
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9883452/
Abstract

m6A is an important RNA methylation in progression of various human cancers. As the m6A reader protein, YTHDF1 is reported to accelerate m6A-modified mRNAs translation in cytoplasm. It is highly expressed in various human cancers and contributes to the progression and metastasis of cancers. YTHDF1 was closely associated with poor prognosis and also used as a molecular marker for clinical diagnosis or therapy in human cancers. It has been reported to promote chemoresistance to Adriamycin, Cisplatin and Olaparib by increasing mRNA stability of its target molecule. Moreover, it contributes to CSC-like characteristic of tumor cells and inducing the antitumor immune microenvironment. Here, we reviewed the clinical diagnostic and prognostic values of YTHDF1, as well as the molecular mechanisms of YTHDF1 in progression and metastasis of human cancers.

摘要

m6A是多种人类癌症进展过程中的一种重要RNA甲基化修饰。作为m6A阅读蛋白，YTHDF1被报道可促进m6A修饰的mRNA在细胞质中的翻译。它在多种人类癌症中高表达，并促进癌症的进展和转移。YTHDF1与不良预后密切相关，也被用作人类癌症临床诊断或治疗的分子标志物。据报道，它通过增加其靶分子的mRNA稳定性来促进对阿霉素、顺铂和奥拉帕尼的化疗耐药性。此外，它有助于肿瘤细胞的癌症干细胞样特性并诱导抗肿瘤免疫微环境。在此，我们综述了YTHDF1的临床诊断和预后价值，以及YTHDF1在人类癌症进展和转移中的分子机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e836/9883452/dcbec28fe3c5/41420_2023_1321_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e836/9883452/a4b8e4eef57b/41420_2023_1321_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e836/9883452/3e6819af8f42/41420_2023_1321_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e836/9883452/73e3ef697463/41420_2023_1321_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e836/9883452/dcbec28fe3c5/41420_2023_1321_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e836/9883452/a4b8e4eef57b/41420_2023_1321_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e836/9883452/3e6819af8f42/41420_2023_1321_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e836/9883452/73e3ef697463/41420_2023_1321_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e836/9883452/dcbec28fe3c5/41420_2023_1321_Fig4_HTML.jpg

相似文献

[1]
The potential role of m6A reader YTHDF1 as diagnostic biomarker and the signaling pathways in tumorigenesis and metastasis in pan-cancer.

Cell Death Discov. 2023-1-28

[2]
The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation.

Nucleic Acids Res. 2020-4-17

[3]
ELK1-mediated YTHDF1 drives prostate cancer progression by facilitating the translation of Polo-like kinase 1 in an m6A dependent manner.

Int J Biol Sci. 2022

[4]
YTHDF1 promotes breast cancer progression by facilitating FOXM1 translation in an m6A-dependent manner.

Cell Biosci. 2022-2-23

[5]
HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation.

Signal Transduct Target Ther. 2021-2-23

[6]
The m6A readers and aberrations associated with metastasis and predict poor prognosis in breast cancer patients.

Am J Cancer Res. 2020-8-1

[7]
m6A-YTHDF1-mediated TRIM29 upregulation facilitates the stem cell-like phenotype of cisplatin-resistant ovarian cancer cells.

Biochim Biophys Acta Mol Cell Res. 2021-1

[8]
The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases.

Mol Ther Nucleic Acids. 2021-11-4

[9]
Methylation recognition protein YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) regulates the proliferation, migration and invasion of osteosarcoma by regulating m6A level of CCR4-NOT transcription complex subunit 7 (CNOT7).

Bioengineered. 2022-3

[10]
The RNA m6A Reader YTHDF1 Is Required for Acute Myeloid Leukemia Progression.

Cancer Res. 2023-3-15

引用本文的文献

[1]
Mechanistic Insights and Clinical Implications of ELK1 in Solid Tumors: A Narrative Review.

Cells. 2025-8-14

[2]
Epigenetic modulation with nanosatellite triggers tumoricidal immunity for hepatocellular carcinoma treatment.

Nat Commun. 2025-8-8

[3]
Thiamine and METTL14 in Diabetes Management with Intensive Insulin Therapy.

Biomedicines. 2025-4-17

[4]
YTHDF1/RNF7/p27 axis promotes prostate cancer progression.

Cell Death Dis. 2025-4-18

[5]
m6A RNA methylation: a pivotal regulator of tumor immunity and a promising target for cancer immunotherapy.

J Transl Med. 2025-2-28

[6]
Cellular senescence: from homeostasis to pathological implications and therapeutic strategies.

Front Immunol. 2025-2-3

[7]
RNA N-Methyladenosine-Binding Protein YTHDFs Redundantly Attenuate Cancer Immunity by Downregulating IFN-γ Signaling in Gastric Cancer.

Adv Sci (Weinh). 2025-1

[8]
Epigenetics of Conjunctival Melanoma: Current Knowledge and Future Directions.

Cancers (Basel). 2024-10-31

[9]
The three YTHDF paralogs and VIRMA are strong cross-histotype tumor driver candidates among mA core genes.

NAR Cancer. 2024-10-15

[10]
Prognostic analysis of patients with gastric cancer based on N-methyladenosine modification patterns and tumor microenvironment characterization.

Front Pharmacol. 2024-8-9

本文引用的文献

[1]
Identification and verification of IGFBP3 and YTHDC1 as biomarkers associated with immune infiltration and mitophagy in hypertrophic cardiomyopathy.

Front Genet. 2022-10-4

[2]
mA regulation of cortical and retinal neurogenesis is mediated by the redundant mA readers YTHDFs.

iScience. 2022-8-11

[3]
METTL3 promotes non-small cell lung cancer (NSCLC) cell proliferation and colony formation in a m6A-YTHDF1 dependent way.

BMC Pulm Med. 2022-8-25

[4]
Mettl3 regulates hypertrophic differentiation of chondrocytes through modulating Dmp1 mRNA via Ythdf1-mediated mA modification.

Bone. 2022-11

[5]
METTL3 promotes cell cycle progression via mA/YTHDF1-dependent regulation of translation.

Int J Biol Sci. 2022

[6]
MEF2C Expression Is Regulated by the Post-transcriptional Activation of the METTL3-mA-YTHDF1 Axis in Myoblast Differentiation.

Front Vet Sci. 2022-4-28

[7]
YTHDF1 alleviates sepsis by upregulating WWP1 to induce NLRP3 ubiquitination and inhibit caspase-1-dependent pyroptosis.

Cell Death Discov. 2022-5-4

[8]
YTHDF1 Negatively Regulates -Induced Inflammation in THP-1 Macrophages by Promoting SOCS3 Translation in an m6A-Dependent Manner.

Front Immunol. 2022

[9]
m6A and YTHDF proteins contribute to the localization of select neuronal mRNAs.

Nucleic Acids Res. 2022-5-6

[10]
Comprehensive Analysis of YTHDF1 Immune Infiltrates and ceRNA in Human Esophageal Carcinoma.

Front Genet. 2022-3-23

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索