m6A阅读蛋白YTHDF1在肿瘤生物学和人类疾病中的作用及机制
The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases.
作者信息
Chen Zuyao, Zhong Xiaolin, Xia Min, Zhong Jing
机构信息
Hengyang Medical School, University of South China, 421001 Hengyang, Hunan, China.
The First Affiliated Hospital, Institute Center of Clinical Medicine, Hengyang Medical School, University of South China, 421001 Hengyang, Hunan, China.
出版信息
Mol Ther Nucleic Acids. 2021 Nov 4;26:1270-1279. doi: 10.1016/j.omtn.2021.10.023. eCollection 2021 Dec 3.
YTHDF1 is the most versatile and powerful reader protein of -methyladenosine (m6A)-modified RNA, and it can recognize both G(m6A)C and A(m6A)C RNAs as ligands without sequence selectivity. YTHDF1 regulates target gene expression by different mechanisms, such as promoting translation or regulating the stability of mRNA. Numerous studies have shown that YTHDF1 plays an important role in tumor biology and nontumor lesions by mediating the protein translation of important genes or by affecting the expression of key factors involved in many important cell signaling pathways. Therefore, in this review we focus on some of the roles of YTHDF1 in tumor biology and diseases.
YTHDF1是N6-甲基腺苷（m6A）修饰RNA最具通用性和强大功能的读取蛋白，它可以将G（m6A）C和A（m6A）C RNA都识别为配体，且无序列选择性。YTHDF1通过不同机制调节靶基因表达，如促进翻译或调节mRNA稳定性。大量研究表明，YTHDF1通过介导重要基因的蛋白质翻译或影响许多重要细胞信号通路中关键因子的表达，在肿瘤生物学和非肿瘤病变中发挥重要作用。因此，在本综述中，我们重点关注YTHDF1在肿瘤生物学和疾病中的一些作用。
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