Zhu Yang, Gong Peng, Wang Jun, Cheng Junjie, Wang Wenyu, Cai Huilan, Ao Rujiang, Huang Hongwei, Yu Meili, Lin Lisen, Chen Xiaoyuan
MOE Key Laboratory for Analytical Science of Food Safety and Biology, Engineering Technology Research Center on Reagent and Instrument for Rapid Detection of Product Quality and Food Safety in Fujian Province, College of Chemistry, Fuzhou University, Fuzhou, 350108, China.
Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and College of Design and Engineering, National University of Singapore, Singapore, 119074, Singapore.
Angew Chem Int Ed Engl. 2023 Mar 13;62(12):e202218407. doi: 10.1002/anie.202218407. Epub 2023 Feb 14.
Lipid peroxidation (LPO) is one of the most damaging processes in chemodynamic therapy (CDT). Although it is well known that polyunsaturated fatty acids (PUFAs) are much more susceptible than saturated or monounsaturated ones to LPO, there is no study exploring the effect of cell membrane unsaturation degree on CDT. Here, we report a self-reinforcing CDT agent (denoted as OA@Fe-SAC@EM NPs), consisting of oleanolic acid (OA)-loaded iron single-atom catalyst (Fe-SAC)-embedded hollow carbon nanospheres encapsulated by an erythrocyte membrane (EM), which promotes LPO to improve chemodynamic efficacy via modulating the degree of membrane unsaturation. Upon uptake of OA@Fe-SAC@EM NPs by cancer cells, Fe-SAC-catalyzed conversion of endogenous hydrogen peroxide into hydroxyl radicals, in addition to initiating the chemodynamic therapeutic process, causes the dissociation of the EM shell and the ensuing release of OA that can enrich cellular membranes with PUFAs, enabling LPO amplification-enhanced CDT.
脂质过氧化（LPO）是化学动力学疗法（CDT）中最具破坏性的过程之一。尽管众所周知，多不饱和脂肪酸（PUFA）比饱和或单不饱和脂肪酸更容易发生LPO，但尚无研究探讨细胞膜不饱和度对CDT的影响。在此，我们报道了一种自增强CDT剂（记为OA@Fe-SAC@EM NPs），它由负载齐墩果酸（OA）的铁单原子催化剂（Fe-SAC）嵌入的中空碳纳米球组成，该纳米球被红细胞膜（EM）包裹，通过调节膜不饱和度促进LPO以提高化学动力学疗效。癌细胞摄取OA@Fe-SAC@EM NPs后，Fe-SAC催化内源性过氧化氢转化为羟基自由基，除了启动化学动力学治疗过程外，还会导致EM外壳解离并随后释放OA，OA可使细胞膜富含PUFA，从而实现LPO放大增强的CDT。
