Chaturvedi Santosh K
Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bangalore 560 029 India.
Pain. 1987 Aug;30(2):159-168. doi: 10.1016/0304-3959(87)91071-2.
Family morbidity in chronic pain patients could indicate genetic vulnerability to depressive spectrum disorders or presence of pain behaviour models. Assessment of family morbidity is an area of chronic pain research which has been neglected. In the present study, the frequency and nature of the family psychiatric morbidity of 203 consecutive chronic pain patients has been assessed and compared with that of 140 non-pain psychiatric patients. 30% of chronic pain patients and 33.6% of non-pain psychiatric patients had family psychiatric morbidity. The commonest illness in families of pain patients were found to be alcoholism, psychosomatic disorders and chronic pain. Schizophrenia and affective disorders were reported significantly more often in families of non-pain patients. 53% of psychogenic pain disorder patients had a positive family morbidity. Alcoholism among male relatives, and chronic pain and hypertension more often among female relatives, was another significant observation. No significant difference was found between chronic pain patients with and without family morbidity with regard to socio-demographic variables and clinical diagnosis.
慢性疼痛患者的家族发病率可能表明其对抑郁谱系障碍存在遗传易感性,或存在疼痛行为模式。家族发病率评估是慢性疼痛研究中一个被忽视的领域。在本研究中,对203例连续的慢性疼痛患者的家族精神疾病发病率的频率和性质进行了评估,并与140例非疼痛性精神疾病患者进行了比较。30%的慢性疼痛患者和33.6%的非疼痛性精神疾病患者有家族精神疾病发病率。疼痛患者家族中最常见的疾病是酗酒、心身疾病和慢性疼痛。非疼痛患者的家族中,精神分裂症和情感障碍的报告明显更多。53%的心因性疼痛障碍患者有阳性家族发病率。男性亲属中的酗酒,以及女性亲属中更常见的慢性疼痛和高血压,是另一个重要发现。在社会人口统计学变量和临床诊断方面,有家族发病率和无家族发病率的慢性疼痛患者之间未发现显著差异。