一项针对精神分裂症患者及正常对照先证者的家系研究：对精神分裂症谱系概念的启示

A family study of schizophrenic and normal control probands: implications for the spectrum concept of schizophrenia.

作者信息

Baron M, Gruen R, Rainer J D, Kane J, Asnis L, Lord S

出版信息

Am J Psychiatry. 1985 Apr;142(4):447-55. doi: 10.1176/ajp.142.4.447.

DOI:10.1176/ajp.142.4.447

Abstract

Morbidity risks for mental illness were determined in 750 first-degree relatives of chronic schizophrenic and normal control probands. Psychiatric disorders that were more frequent in relatives of schizophrenic probands than in relatives of normal control probands were chronic schizophrenia (5.8% versus 0.6%), schizotypal personality disorder (definite, 14.6% versus 2.1%; probable, 12.1% versus 6.5%), and paranoid personality disorder (7.3% versus 2.3%). The data suggest that schizotypal and paranoid personality disorders are genetically related to schizophrenia. The implications for schizophrenia research are discussed.

摘要

研究测定了750名慢性精神分裂症患者的一级亲属以及正常对照先证者的精神疾病发病风险。相较于正常对照先证者的亲属，精神分裂症先证者的亲属中更常见的精神疾病有慢性精神分裂症（5.8% 对0.6%）、分裂型人格障碍（确诊，14.6% 对2.1%；可能，12.1% 对6.5%）以及偏执型人格障碍（7.3% 对2.3%）。数据表明，分裂型和偏执型人格障碍与精神分裂症存在遗传相关性。本文讨论了这些发现对精神分裂症研究的意义。