Department of Civil Engineering, Materials and Manufacturing, School of Engineering, University of Malaga, Spain; Eaton-Peabody Laboratory, Massachusetts Eye and Ear, Boston, MA, USA; Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Boston, MA, USA.
Center for Holographic Studies and Laser micro-mechaTronics (CHSLT), Worcester, MA, USA; Mechanical Engineering Department, Worcester Polytechnic Institute, Worcester, MA, USA.
Acta Biomater. 2023 Mar 15;159:63-73. doi: 10.1016/j.actbio.2023.01.048. Epub 2023 Jan 26.
A methodology for the development of a finite element numerical model of the tympanic membrane (TM) based on experiments carried out in the time domain on a cadaveric human temporal bone is presented. Using a high-speed digital holographic (HDH) system, acoustically-induced transient displacements of the TM surface are obtained. The procedure is capable to generate and validate the finite element model of the TM by numerical and experimental data correlation. Reverse engineering approach is used to identify key material parameters that define the mechanical response of the TM. Finally, modal numerical simulations of the specimen are performed. Results show the feasibility of the methodology to obtain an accurate model of a specific specimen and to help interpret its behaviour with additional numerical simulations. STATEMENT OF SIGNIFICANCE: Improving knowledge of the dynamic behavior of the tympanic membrane is key to understanding the sound transmission system in human hearing and advance in the treatment of its pathologies. Recently we acquired a new tool to carry out experiments in transient regime by means of digital laser holography, capable of providing a large amount of information in a controlled transient test. In this work, these data are used to develop a methodology that generates a numerical model of the tympanic membrane based on numerical-experimental correlations. It is important to be able to develop models that fit specific patients. In this work, additional modal simulations are also presented that, in addition to validating the results, provide more information on the specimen.
本文提出了一种基于尸体颞骨时域实验的鼓膜（TM）有限元数值模型开发方法。使用高速数字全息（HDH）系统，获得 TM 表面的声致瞬态位移。该方法能够通过数值和实验数据的相关性生成和验证 TM 的有限元模型。采用反向工程方法来识别定义 TM 力学响应的关键材料参数。最后，对样品进行模态数值模拟。结果表明，该方法能够获得特定样品的精确模型，并通过附加数值模拟帮助解释其行为，具有可行性。
提高对鼓膜动态行为的认识是理解人类听力传音系统和推进其病理治疗的关键。最近，我们获得了一种新的工具，通过数字激光全息术在瞬态条件下进行实验，能够在受控的瞬态测试中提供大量信息。在这项工作中，这些数据被用于开发一种基于数值-实验相关性的 TM 数值模型生成方法。能够为特定患者开发合适的模型非常重要。在这项工作中，还提出了其他模态模拟，除了验证结果外，还提供了有关样品的更多信息。
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