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正常耳与实验模拟病理耳中鼓膜的高速全息形状及全场位移测量

High-Speed Holographic Shape and Full-Field Displacement Measurements of the Tympanic Membrane in Normal and Experimentally Simulated Pathological Ears.

作者信息

Tang Haimi, Razavi Payam, Pooladvand Koohyar, Psota Pavel, Maftoon Nima, Rosowski John J, Furlong Cosme, Cheng Jeffrey T

机构信息

Center for Holographic Studies and Laser Micro-mechaTronics (CHSLT), Worcester, MA 01609, USA.

Mechanical Engineering Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA.

出版信息

Appl Sci (Basel). 2019 Jul 2;9(14). doi: 10.3390/app9142809. Epub 2019 Jul 13.

DOI:10.3390/app9142809
PMID:32802482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7425804/
Abstract

To improve the understanding of the middle-ear hearing mechanism and assist in the diagnosis of middle-ear diseases, we are developing a high-speed digital holographic (HDH) system to measure the shape and acoustically-induced transient displacements of the tympanic membrane (TM). In this paper, we performed measurements on cadaveric human ears with simulated common middle-ear pathologies. The frequency response function (FRF) of the normalized displacement by the stimulus (sound pressure) at each measured pixel point of the entire TM surface was calculated and the complex modal indicator function (CMIF) of the middle-ear system based on FRFs of the entire TM surface motions was used to differentiate different middle-ear pathologies. We also observed changes in the TM shape and the surface motion pattern before and after various middle-ear manipulations. The observations of distinguishable TM shapes and motion patterns in both time and frequency domains between normal and experimentally simulated pathological ears support the development of a quantitative clinical holography-based apparatus for diagnosing middle-ear pathologies.

摘要

为了增进对中耳听觉机制的理解并辅助中耳疾病的诊断，我们正在开发一种高速数字全息（HDH）系统，以测量鼓膜（TM）的形状和声致瞬态位移。在本文中，我们对具有模拟常见中耳病变的人体尸体耳朵进行了测量。计算了整个TM表面每个测量像素点处刺激（声压）引起的归一化位移的频率响应函数（FRF），并基于整个TM表面运动的FRF使用中耳系统的复模态指标函数（CMIF）来区分不同的中耳病变。我们还观察了各种中耳操作前后TM形状和表面运动模式的变化。正常耳朵与实验模拟的病理耳朵在时域和频域中可区分的TM形状和运动模式的观察结果支持了基于定量临床全息术的中耳病变诊断设备的开发。

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