主要和中介效应：多种共病与抑郁症状对认知的影响。
Main and moderated effects of multimorbidity and depressive symptoms on cognition.
机构信息
Centro de Integração de Dados e Conhecimentos para Saúde, Fundação Oswaldo Cruz-Fiocruz, Salvador, BA, Brazil.
Centro de Integração de Dados e Conhecimentos para Saúde, Fundação Oswaldo Cruz-Fiocruz, Salvador, BA, Brazil. Universidade Federal do Ceará, Itapajé, CE, Brazil.
出版信息
Braz J Psychiatry. 2022 Sep 30;44(6):644-649. doi: 10.47626/1516-4446-2022-2601.
OBJECTIVE
Multimorbidity, or the occurrence of two or more chronic conditions, is a global challenge, with implications for mortality, morbidity, disability, and life quality. Psychiatric disorders are common among the chronic diseases that affect patients with multimorbidity. It is still not well understood whether psychiatric symptoms, especially depressive symptoms, moderate the effect of multimorbidity on cognition.
METHODS
We used a large (n=2,681) dataset to assess whether depressive symptomatology moderates the effect of multimorbidity on cognition using structural equation modelling.
RESULTS
It was found that the more depressive symptoms and chronic conditions, the worse the cognitive performance, and the higher the educational level, the better the cognitive performance. We found a significant but weak (0.009; p = 0.04) moderating effect.
CONCLUSION
We have provided the first estimate of the moderating effect of depression on the relation between multimorbidity and cognition, which was small. Although this moderation has been implied by many previous studies, it was never previously estimated.
目的
多种疾病（同时患有两种或两种以上的慢性疾病）是一个全球性的挑战，对死亡率、发病率、残疾和生活质量都有影响。在影响多种疾病患者的慢性疾病中，精神障碍较为常见。精神症状，尤其是抑郁症状是否会缓和多种疾病对认知的影响，目前仍不甚清楚。
方法
我们使用一个大型数据集（n=2681），通过结构方程模型评估抑郁症状是否会缓和多种疾病对认知的影响。
结果
结果发现，抑郁症状和慢性疾病越多，认知表现越差；教育程度越高，认知表现越好。我们发现了一个显著但较弱的（0.009；p=0.04）调节作用。
结论
我们首次对抑郁对多种疾病与认知之间关系的调节作用进行了估计，其影响很小。虽然许多先前的研究都暗示了这种调节作用，但以前从未进行过估计。
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